CRCGN010_HEPG2_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 20.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN010_HEPG2_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 6.02538
NANOS3 nanos homolog 3 (Drosophila) 5.28938
PRR15L proline rich 15-like 5.28038
E2F2 E2F transcription factor 2 4.92179
CARMIL1 capping protein regulator and myosin 1 linker 1 4.91099
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.87706
C2CD2 C2 calcium-dependent domain containing 2 4.79469
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.74425
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.69822
ABHD6 abhydrolase domain containing 6 4.67581
TATDN2 TatD DNase domain containing 2 4.26521
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.26239
JADE2 jade family PHD finger 2 4.1944
TESK1 testis-specific kinase 1 4.08749
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.68585
KIFBP kinesin family binding protein 3.58417
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.58343
ZBTB35 zinc finger and BTB domain containing 35 3.57597
TIAM1 T-cell lymphoma invasion and metastasis 1 3.5493
MOK MOK protein kinase 3.53529
HOXA10 homeobox A10 3.4927
SPTAN1 spectrin, alpha, non-erythrocytic 1 3.37664
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.36222
CDPF1 cysteine-rich, DPF motif domain containing 1 3.26129
INSIG1 insulin induced gene 1 3.24865
KLHL9 kelch-like family member 9 3.00841
PARP1 poly (ADP-ribose) polymerase 1 2.96422
TRAM2 translocation associated membrane protein 2 2.94095
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.88946
CCL2 chemokine (C-C motif) ligand 2 2.78377
PLPP1 phospholipid phosphatase 1 2.73646
LPAR2 lysophosphatidic acid receptor 2 2.71863
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.71568
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.70669
NOSIP nitric oxide synthase interacting protein 2.69536
HLA-DMA major histocompatibility complex, class II, DM alpha 2.68987
CRTAP cartilage associated protein 2.59292
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.58419
FPGS folylpolyglutamate synthase 2.51872
HLA-DRA major histocompatibility complex, class II, DR alpha 2.50922
MEST mesoderm specific transcript 2.50724
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.50674
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.50149
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 2.45112
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.44707
DOLK dolichol kinase 2.42964
LCN2 lipocalin 2 2.41036
MCOLN1 mucolipin 1 2.3279
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.31016
FOXJ3 forkhead box J3 2.29744
OXCT1 3-oxoacid CoA transferase 1 2.27449
FOXM1 forkhead box M1 2.26098
HBA1 hemoglobin, alpha 1 2.25874
PROCR protein C receptor, endothelial 2.2162
ZNF638 zinc finger protein 638 2.20096
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 2.18946
PTK2 protein tyrosine kinase 2 2.17437
STXBP2 syntaxin binding protein 2 2.14638
MAP2K5 mitogen-activated protein kinase kinase 5 2.12972
CSK c-src tyrosine kinase 2.12277
ZIC1 Zic family member 1 2.12182
STX1A syntaxin 1A (brain) 2.11149
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.10327
DBN1 drebrin 1 2.10266
ADGRE5 adhesion G protein-coupled receptor E5 2.09626
ASB8 ankyrin repeat and SOCS box containing 8 2.09528
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.09165
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.06466
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.04235

decreased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 -5.82912
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.48192
COG2 component of oligomeric golgi complex 2 -5.06013
FBXL12 F-box and leucine-rich repeat protein 12 -4.94721
NT5DC2 5'-nucleotidase domain containing 2 -4.91504
MAPK13 mitogen-activated protein kinase 13 -4.78416
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.6643
TM9SF3 transmembrane 9 superfamily member 3 -4.65472
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.39187
ZW10 zw10 kinetochore protein -4.28772
RAI14 retinoic acid induced 14 -4.17606
CD320 CD320 molecule -4.17132
ZNF586 zinc finger protein 586 -3.89772
NGRN neugrin, neurite outgrowth associated -3.7254
YME1L1 YME1-like 1 ATPase -3.6882
LOC124907782 dual specificity protein phosphatase 22 -3.51814
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.48782
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.43504
HEATR1 HEAT repeat containing 1 -3.39239
NRIP1 nuclear receptor interacting protein 1 -3.27295
CORO1A coronin, actin binding protein, 1A -3.12853
CCNB2 cyclin B2 -3.04786
RPS5 ribosomal protein S5 -2.90348
VDAC1 voltage-dependent anion channel 1 -2.74936
GTPBP8 GTP-binding protein 8 (putative) -2.74652
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.72762
BLMH bleomycin hydrolase -2.62004
TWF2 twinfilin actin binding protein 2 -2.60267
RPIA ribose 5-phosphate isomerase A -2.51683
SNX6 sorting nexin 6 -2.4868
TCTN1 tectonic family member 1 -2.47827
FOS FBJ murine osteosarcoma viral oncogene homolog -2.46463
PDLIM1 PDZ and LIM domain 1 -2.27863
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.26862
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.26613
UFM1 ubiquitin-fold modifier 1 -2.26609
DYNLT3 dynein, light chain, Tctex-type 3 -2.26441
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.25726
GSTA4 glutathione S-transferase alpha 4 -2.18514
ZBED2 zinc finger, BED-type containing 2 -2.1449
GNB5 guanine nucleotide binding protein (G protein), beta 5 -2.14049
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.13518
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.13027
ZMAT5 zinc finger, matrin-type 5 -2.12423
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.122
CLCA2 chloride channel accessory 2 -2.12129
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -2.08248
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.05432
CUL7 cullin 7 -2.0385
IQCB1 IQ motif containing B1 -2.03214
ETFB electron-transfer-flavoprotein, beta polypeptide -2.02821
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.00929