CRCGN010_HEPG2_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 2.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN010_HEPG2_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.68297
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.12038
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.88844
CBR3 carbonyl reductase 3 4.88158
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.86579
CCL2 chemokine (C-C motif) ligand 2 4.57535
UBQLN2 ubiquilin 2 4.42362
GPATCH8 G patch domain containing 8 4.40816
STK10 serine/threonine kinase 10 4.34797
DIPK1A divergent protein kinase domain 1A 4.30598
KLHL9 kelch-like family member 9 3.65026
HLA-DMA major histocompatibility complex, class II, DM alpha 3.49423
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.09755
VGLL4 vestigial-like family member 4 3.0918
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.04696
RPP38 ribonuclease P/MRP 38kDa subunit 2.96855
MEST mesoderm specific transcript 2.79054
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.74249
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.71996
EXTL2 exostosin-like glycosyltransferase 2 2.66569
PRR15L proline rich 15-like 2.59877
CARMIL1 capping protein regulator and myosin 1 linker 1 2.49899
ZNF589 zinc finger protein 589 2.32141
PLSCR3 phospholipid scramblase 3 2.23065
FSD1 fibronectin type III and SPRY domain containing 1 2.15788
CHMP6 charged multivesicular body protein 6 2.15183
SIRT3 sirtuin 3 2.10659
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.08256
SKIC8 SKI8 subunit of superkiller complex 2.07365
IGFBP3 insulin-like growth factor binding protein 3 2.04718
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.02989

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.44505
ZNF586 zinc finger protein 586 -5.22757
CDC20 cell division cycle 20 -5.10152
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.04901
LDHD lactate dehydrogenase D -4.77914
OXA1L oxidase (cytochrome c) assembly 1-like -4.49001
ZMIZ1 zinc finger, MIZ-type containing 1 -4.47341
ACAA1 acetyl-CoA acyltransferase 1 -4.30715
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.78461
PRPF4 pre-mRNA processing factor 4 -3.71373
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.39979
CCNB2 cyclin B2 -2.94103
USP6NL USP6 N-terminal like -2.89752
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.71137
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.66475
FBXL12 F-box and leucine-rich repeat protein 12 -2.40606
ARID5B AT rich interactive domain 5B (MRF1-like) -2.37552
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.30802
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.18982
PPOX protoporphyrinogen oxidase -2.08349
XPO7 exportin 7 -2.06067
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.01395