CRCGN010_HEPG2_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylethylketoxime 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN010_HEPG2_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.74198
E2F2 E2F transcription factor 2 7.31192
CXCL2 chemokine (C-X-C motif) ligand 2 7.1837
CIAO3 cytosolic iron-sulfur assembly component 3 6.29956
EVL Enah/Vasp-like 5.83424
LCN2 lipocalin 2 5.11649
TIAM1 T-cell lymphoma invasion and metastasis 1 4.82113
BZW2 basic leucine zipper and W2 domains 2 3.82266
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.64643
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.62389
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.57174
CHMP6 charged multivesicular body protein 6 3.49561
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.37727
RPP38 ribonuclease P/MRP 38kDa subunit 3.3017
RAB21 RAB21, member RAS oncogene family 3.26035
AMDHD2 amidohydrolase domain containing 2 2.84182
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.82891
STIMATE STIM activating enhancer 2.66141
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.50489
FZD7 frizzled class receptor 7 2.48509
BIRC2 baculoviral IAP repeat containing 2 2.47524
LPAR2 lysophosphatidic acid receptor 2 2.45467
VGLL4 vestigial-like family member 4 2.38889
CHEK2 checkpoint kinase 2 2.36809
GATA2 GATA binding protein 2 2.32331
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.24295
APOA4 apolipoprotein A-IV 2.17346
ADGRB1 adhesion G protein-coupled receptor B1 2.16437
XAB2 XPA binding protein 2 2.14145
WDR18 WD repeat domain 18 2.02677
CXCL3 chemokine (C-X-C motif) ligand 3 2.00451

decreased expression

Symbol Name Standardized Value
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -7.1385
CHMP4B charged multivesicular body protein 4B -5.93267
TLR4 toll-like receptor 4 -4.68731
DERA deoxyribose-phosphate aldolase (putative) -4.57882
OXA1L oxidase (cytochrome c) assembly 1-like -4.45712
LAP3 leucine aminopeptidase 3 -4.09795
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.89008
MRPS2 mitochondrial ribosomal protein S2 -3.67074
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.66611
PCNA proliferating cell nuclear antigen -3.64927
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.56728
THAP11 THAP domain containing 11 -3.47348
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.46006
TRIB3 tribbles pseudokinase 3 -3.42067
NT5DC2 5'-nucleotidase domain containing 2 -3.36341
EIF5 eukaryotic translation initiation factor 5 -3.21194
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.13364
KDM3A lysine (K)-specific demethylase 3A -3.10873
DPH2 DPH2 homolog (S. cerevisiae) -3.09261
LDHD lactate dehydrogenase D -3.08304
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.96163
VAT1 vesicle amine transport 1 -2.9505
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.9237
RAI14 retinoic acid induced 14 -2.88534
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.77342
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.70669
LOC124907782 dual specificity protein phosphatase 22 -2.63239
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.58745
WASHC4 WASH complex subunit 4 -2.56461
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.55437
CDC20 cell division cycle 20 -2.49141
ARL4A ADP-ribosylation factor-like 4A -2.37273
UGDH UDP-glucose 6-dehydrogenase -2.33127
TOR1A torsin family 1, member A (torsin A) -2.27598
GPR183 G protein-coupled receptor 183 -2.1671
NVL nuclear VCP-like -2.13386
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.04635
TBPL1 TBP-like 1 -2.0147