CRCGN010_HEPG2_24H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylethylketoxime 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN010_HEPG2_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 10.0
E2F2 E2F transcription factor 2 10.0
AMDHD2 amidohydrolase domain containing 2 6.75025
CHN1 chimerin 1 5.5339
DYNLT3 dynein, light chain, Tctex-type 3 5.50137
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.85147
CSK c-src tyrosine kinase 3.66228
EAPP E2F-associated phosphoprotein 3.57786
SYNE2 spectrin repeat containing, nuclear envelope 2 3.37727
NMU neuromedin U 3.33649
NOTCH1 notch 1 3.278
MYLK myosin light chain kinase 3.19806
CIAO3 cytosolic iron-sulfur assembly component 3 3.10135
CHMP6 charged multivesicular body protein 6 3.06842
STK10 serine/threonine kinase 10 3.05604
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.88539
CXCL2 chemokine (C-X-C motif) ligand 2 2.81146
EPHB2 EPH receptor B2 2.75248
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.56625
ONECUT2 one cut homeobox 2 2.56159
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.52797
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.47138
GSTZ1 glutathione S-transferase zeta 1 2.47046
TIAM1 T-cell lymphoma invasion and metastasis 1 2.43754
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.41463
ANGPT4 angiopoietin 4 2.41118
CCL24 chemokine (C-C motif) ligand 24 2.3945
CBR3 carbonyl reductase 3 2.38175
LOC122526780 uncharacterized LOC122526780 2.37123
MCUR1 mitochondrial calcium uniporter regulator 1 2.36257
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.3286
HLA-DMA major histocompatibility complex, class II, DM alpha 2.32532
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.26804
PCDHB13 protocadherin beta 13 2.258
TENM3 teneurin transmembrane protein 3 2.20924
MYH13 myosin, heavy chain 13, skeletal muscle 2.20682
PKD2L1 polycystic kidney disease 2-like 1 2.19883
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.19241
ADGRB1 adhesion G protein-coupled receptor B1 2.18633
ABHD6 abhydrolase domain containing 6 2.1775
LIMK1 LIM domain kinase 1 2.17446
LHX5 LIM homeobox 5 2.16715
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.14882
TOM1L2 target of myb1-like 2 (chicken) 2.11032
CLDN14 claudin 14 2.10101
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.09444
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.07312
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.07201
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.05995
FBXO24 F-box protein 24 2.05961
ZSCAN2 zinc finger and SCAN domain containing 2 2.05569
PCDHB6 protocadherin beta 6 2.04706
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.04307
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 2.03434
NPAS1 neuronal PAS domain protein 1 2.03298
HROB homologous recombination factor with OB-fold 2.03155
JMJD7 jumonji domain containing 7 2.03146
AMBN ameloblastin (enamel matrix protein) 2.02546
HOXA6 homeobox A6 2.02237
GTF2A2 general transcription factor IIA, 2, 12kDa 2.01037
LBX1 ladybird homeobox 1 2.00422

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ZDHHC6 zinc finger, DHHC-type containing 6 -6.52123
CDC20 cell division cycle 20 -6.26591
CCDC86 coiled-coil domain containing 86 -3.72352
NT5DC2 5'-nucleotidase domain containing 2 -3.62637
TSPAN4 tetraspanin 4 -3.59184
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.45539
SLC35F2 solute carrier family 35, member F2 -3.26387
DNM1L dynamin 1-like -3.16875
CCNB2 cyclin B2 -3.02045
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.01428
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.94726
PCNA proliferating cell nuclear antigen -2.82165
TM9SF3 transmembrane 9 superfamily member 3 -2.77159
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.46287
CCNB1 cyclin B1 -2.40172
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.28989
MSRA methionine sulfoxide reductase A -2.23523
SFRP1 secreted frizzled-related protein 1 -2.16162
TLCD3A TLC domain containing 3A -2.15911
FBXL12 F-box and leucine-rich repeat protein 12 -2.04309