CRCGN010_HEPG2_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylethylketoxime 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

190 genes differentially expressed following the CRCGN010_HEPG2_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 8.11533
MAP7 microtubule-associated protein 7 7.68755
MAMLD1 mastermind-like domain containing 1 7.48671
ADGRE5 adhesion G protein-coupled receptor E5 6.68241
PPARG peroxisome proliferator-activated receptor gamma 6.57135
CCDC92 coiled-coil domain containing 92 5.35181
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.78797
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.63597
NANOS3 nanos homolog 3 (Drosophila) 4.10997
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.8698
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.79767
PLSCR1 phospholipid scramblase 1 3.59796
DENND2D DENN/MADD domain containing 2D 3.52339
RPP38 ribonuclease P/MRP 38kDa subunit 3.38349
STK10 serine/threonine kinase 10 3.36209
RAB21 RAB21, member RAS oncogene family 3.35077
SH3D19 SH3 domain containing 19 3.34454
SATB1 SATB homeobox 1 3.32037
PRKX protein kinase, X-linked 3.25944
FAM20B family with sequence similarity 20, member B 3.22599
SQOR sulfide quinone oxidoreductase 3.21699
GPER1 G protein-coupled estrogen receptor 1 3.18335
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.1667
CRTAP cartilage associated protein 3.16252
ARHGAP1 Rho GTPase activating protein 1 3.11861
IDE insulin-degrading enzyme 3.1139
EML3 echinoderm microtubule associated protein like 3 3.10032
WDR7 WD repeat domain 7 3.07623
MTERF3 mitochondrial transcription termination factor 3 3.0725
KIFBP kinesin family binding protein 3.03758
PLS1 plastin 1 3.01522
LCN2 lipocalin 2 3.00086
LSR lipolysis stimulated lipoprotein receptor 3.00049
HLA-DMA major histocompatibility complex, class II, DM alpha 2.94429
LOC122526780 uncharacterized LOC122526780 2.92596
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.91619
DYNLT3 dynein, light chain, Tctex-type 3 2.88625
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.83865
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.81927
WFDC1 WAP four-disulfide core domain 1 2.73818
CHEK2 checkpoint kinase 2 2.72273
HDGFL3 HDGF like 3 2.7149
STIMATE STIM activating enhancer 2.67389
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.61081
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.56191
PRAF2 PRA1 domain family, member 2 2.5498
CTSW cathepsin W 2.54951
AMHR2 anti-Mullerian hormone receptor, type II 2.54771
ZNF165 zinc finger protein 165 2.53661
CBR3 carbonyl reductase 3 2.53123
SCYL3 SCY1-like 3 (S. cerevisiae) 2.52797
LPAR2 lysophosphatidic acid receptor 2 2.51272
CCDC85B coiled-coil domain containing 85B 2.50556
CCNH cyclin H 2.47414
STAU2 staufen double-stranded RNA binding protein 2 2.46484
PARP8 poly (ADP-ribose) polymerase family, member 8 2.4484
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.43384
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.39263
FAIM Fas apoptotic inhibitory molecule 2.37082
KCTD5 potassium channel tetramerization domain containing 5 2.33895
CORO1A coronin, actin binding protein, 1A 2.33823
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.32078
INSL3 insulin-like 3 (Leydig cell) 2.31938
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.3184
GSTZ1 glutathione S-transferase zeta 1 2.31569
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.31088
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.30384
CCNA1 cyclin A1 2.29956
RASL12 RAS-like, family 12 2.29493
INSIG1 insulin induced gene 1 2.28046
PLSCR3 phospholipid scramblase 3 2.26537
KAT6A K(lysine) acetyltransferase 6A 2.24076
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.23283
LIMS2 LIM and senescent cell antigen-like domains 2 2.22702
RXYLT1 ribitol xylosyltransferase 1 2.22576
UBFD1 ubiquitin family domain containing 1 2.22353
DSCC1 DNA replication and sister chromatid cohesion 1 2.21034
SCRG1 stimulator of chondrogenesis 1 2.20758
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.20696
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.19783
ITGA9 integrin, alpha 9 2.19107
SPAG1 sperm associated antigen 1 2.18696
CD247 CD247 molecule 2.17209
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.16504
GPC1 glypican 1 2.16459
TYW2 tRNA wybutosine-synthesizing protein 2 2.16419
CDK6 cyclin-dependent kinase 6 2.15789
MBNL2 muscleblind-like splicing regulator 2 2.15284
MXRA7 matrix-remodelling associated 7 2.1456
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.14461
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.14376
SOCS2 suppressor of cytokine signaling 2 2.13428
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.12545
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.11419
KIF11 kinesin family member 11 2.1139
PTK6 protein tyrosine kinase 6 2.10571
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.09713
ABHD6 abhydrolase domain containing 6 2.09136
GATA2 GATA binding protein 2 2.08775
GRWD1 glutamate-rich WD repeat containing 1 2.07179
MT1M metallothionein 1M 2.06998
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.05877
TTC28 tetratricopeptide repeat domain 28 2.05445
KCTD11 potassium channel tetramerization domain containing 11 2.0529
TSC22D1 TSC22 domain family, member 1 2.04084
PDYN prodynorphin 2.03698
S100A1 S100 calcium binding protein A1 2.03457
DPYSL3 dihydropyrimidinase-like 3 2.02695
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 2.01743
CHRM4 cholinergic receptor, muscarinic 4 2.01236

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -7.16177
FBXL12 F-box and leucine-rich repeat protein 12 -6.67739
TRIB3 tribbles pseudokinase 3 -6.59637
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.59402
TCTN1 tectonic family member 1 -6.31724
OXA1L oxidase (cytochrome c) assembly 1-like -5.94834
YME1L1 YME1-like 1 ATPase -5.10523
MRPS2 mitochondrial ribosomal protein S2 -4.67028
NVL nuclear VCP-like -4.50213
TLR4 toll-like receptor 4 -4.32306
GSTM2 glutathione S-transferase mu 2 (muscle) -4.23391
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.09264
ZMIZ1 zinc finger, MIZ-type containing 1 -4.06745
GOLT1B golgi transport 1B -3.94727
RPN1 ribophorin I -3.92859
CCDC86 coiled-coil domain containing 86 -3.90016
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.80795
PCNA proliferating cell nuclear antigen -3.71276
XPO7 exportin 7 -3.68836
RPIA ribose 5-phosphate isomerase A -3.59635
HMG20B high mobility group 20B -3.42243
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.40642
LDHD lactate dehydrogenase D -3.3621
DSG2 desmoglein 2 -3.31657
PRCP prolylcarboxypeptidase (angiotensinase C) -3.29456
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.25925
CCNB2 cyclin B2 -3.2089
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.10352
SLC35F2 solute carrier family 35, member F2 -3.10115
RBM15B RNA binding motif protein 15B -3.03437
ZNF586 zinc finger protein 586 -2.98142
PRPF4 pre-mRNA processing factor 4 -2.93083
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.87926
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.85905
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.77063
WASHC4 WASH complex subunit 4 -2.76885
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.73124
DERA deoxyribose-phosphate aldolase (putative) -2.71277
FGFR4 fibroblast growth factor receptor 4 -2.63823
STAT1 signal transducer and activator of transcription 1, 91kDa -2.61874
ENOPH1 enolase-phosphatase 1 -2.57689
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.54407
DPH2 DPH2 homolog (S. cerevisiae) -2.53279
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.46964
PMPCA peptidase (mitochondrial processing) alpha -2.44292
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.43758
PEG10 paternally expressed 10 -2.43557
NLRP2B NLR family pyrin domain containing 2B -2.42919
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.4205
EIF5 eukaryotic translation initiation factor 5 -2.41117
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.41108
GNAS GNAS complex locus -2.36791
LOC124907782 dual specificity protein phosphatase 22 -2.36271
BLCAP bladder cancer associated protein -2.3485
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.32702
HP1BP3 heterochromatin protein 1, binding protein 3 -2.28979
SETBP1 SET binding protein 1 -2.2894
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.2752
LYPLA1 lysophospholipase I -2.26738
GPC3 glypican 3 -2.24673
KDM1A lysine (K)-specific demethylase 1A -2.24591
CD58 CD58 molecule -2.23521
COPS4 COP9 signalosome subunit 4 -2.23262
FOXO4 forkhead box O4 -2.21771
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.21193
HTATSF1 HIV-1 Tat specific factor 1 -2.19722
ECSIT ECSIT signalling integrator -2.13497
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.13271
GNPAT glyceronephosphate O-acyltransferase -2.1153
AUH AU RNA binding protein/enoyl-CoA hydratase -2.09719
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.08496
TMEM106C transmembrane protein 106C -2.08392
TYK2 tyrosine kinase 2 -2.08313
COQ4 coenzyme Q4 -2.07004
SNX11 sorting nexin 11 -2.06011
RNF11 ring finger protein 11 -2.05864
CDKL3 cyclin-dependent kinase-like 3 -2.0322
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.03201
P3H1 prolyl 3-hydroxylase 1 -2.01356
YY1 YY1 transcription factor -2.00881