CRCGN010_HEPG2_24H:C18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylethylketoxime 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN010_HEPG2_24H:C18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 5.97566
ADGRE5 adhesion G protein-coupled receptor E5 5.14327
EAPP E2F-associated phosphoprotein 4.71
MYLK myosin light chain kinase 4.65269
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.36791
PPARG peroxisome proliferator-activated receptor gamma 4.19853
JADE2 jade family PHD finger 2 3.70891
CARMIL1 capping protein regulator and myosin 1 linker 1 3.49746
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.26786
SQOR sulfide quinone oxidoreductase 3.23621
SCRN1 secernin 1 3.14813
GPATCH8 G patch domain containing 8 3.11846
SIRT3 sirtuin 3 2.65222
ZNF589 zinc finger protein 589 2.589
LPAR2 lysophosphatidic acid receptor 2 2.33797
PYDC1 PYD (pyrin domain) containing 1 2.32936
SMAD3 SMAD family member 3 2.26058
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.03999
CYCS cytochrome c, somatic 2.02976

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.52691
GOLT1B golgi transport 1B -5.13951
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.92592
KDM3A lysine (K)-specific demethylase 3A -4.88991
THAP11 THAP domain containing 11 -4.78719
CCNB2 cyclin B2 -4.7008
FASTKD5 FAST kinase domains 5 -4.46266
DSG2 desmoglein 2 -4.35396
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.20464
TLR4 toll-like receptor 4 -3.90629
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.33821
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.04833
OXA1L oxidase (cytochrome c) assembly 1-like -2.87168
YME1L1 YME1-like 1 ATPase -2.85933
TLCD3A TLC domain containing 3A -2.67341
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.61402
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.54735
IFRD2 interferon-related developmental regulator 2 -2.47728
EIF5 eukaryotic translation initiation factor 5 -2.3947
VDAC1 voltage-dependent anion channel 1 -2.31877
CD58 CD58 molecule -2.28542
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.28141
ZW10 zw10 kinetochore protein -2.27162
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.20129