CRCGN010_HEPG2_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexylresorcinol 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN010_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.47226
MEST mesoderm specific transcript 6.99076
PMM2 phosphomannomutase 2 5.71313
EGF epidermal growth factor 4.90364
E2F2 E2F transcription factor 2 4.8643
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.67415
STK10 serine/threonine kinase 10 4.64128
CYCS cytochrome c, somatic 4.51597
FOXO4 forkhead box O4 4.36859
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.3316
GSTZ1 glutathione S-transferase zeta 1 4.11938
MAP7 microtubule-associated protein 7 4.00292
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.93766
PLSCR1 phospholipid scramblase 1 3.75115
GPER1 G protein-coupled estrogen receptor 1 3.61841
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.54656
PRKCH protein kinase C, eta 3.45881
LPAR2 lysophosphatidic acid receptor 2 3.41599
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.38957
SOCS2 suppressor of cytokine signaling 2 3.34391
TIAM1 T-cell lymphoma invasion and metastasis 1 3.28099
HLA-DMA major histocompatibility complex, class II, DM alpha 3.22683
H2BC12 H2B clustered histone 12 3.12881
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.08245
ADGRD2 adhesion G protein-coupled receptor D2 2.77055
CCNA1 cyclin A1 2.75019
GPATCH8 G patch domain containing 8 2.50252
EPHA3 EPH receptor A3 2.49614
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.47108
DMTF1 cyclin D binding myb-like transcription factor 1 2.46166
SCYL3 SCY1-like 3 (S. cerevisiae) 2.44501
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.40872
H2BC3 H2B clustered histone 3 2.39115
FGF14 fibroblast growth factor 14 2.38425
FAM110D family with sequence similarity 110, member D 2.37375
OGN osteoglycin 2.29668
CNPY4 canopy FGF signaling regulator 4 2.25914
FABP2 fatty acid binding protein 2, intestinal 2.24865
SCFD1 sec1 family domain containing 1 2.24063
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.21859
GPR25 G protein-coupled receptor 25 2.21849
ZNF37A zinc finger protein 37A 2.2113
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.20158
ARMC6 armadillo repeat containing 6 2.18849
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.15308
LHFPL6 LHFPL tetraspan subfamily member 6 2.14873
LRRC31 leucine rich repeat containing 31 2.14515
FRRS1L ferric-chelate reductase 1-like 2.1438
JADE2 jade family PHD finger 2 2.14135
MROH9 maestro heat-like repeat family member 9 2.13847
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.13591
SOX30 SRY (sex determining region Y)-box 30 2.13448
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.12723
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.07781
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.06487
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.04561
GPR162 G protein-coupled receptor 162 2.01517
ZIC4 Zic family member 4 2.01083
GPR85 G protein-coupled receptor 85 2.01031
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 2.00636
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 2.00634
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.00491
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.00233

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -8.08918
PCNA proliferating cell nuclear antigen -4.92647
GOLT1B golgi transport 1B -4.64194
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.31415
CCNB2 cyclin B2 -4.14407
TRIB3 tribbles pseudokinase 3 -4.09226
CCDC86 coiled-coil domain containing 86 -3.85246
LOC124907782 dual specificity protein phosphatase 22 -3.74737
FGFR4 fibroblast growth factor receptor 4 -3.52984
SCCPDH saccharopine dehydrogenase (putative) -3.43928
NRIP1 nuclear receptor interacting protein 1 -2.83354
SLC35F2 solute carrier family 35, member F2 -2.82286
EIF5 eukaryotic translation initiation factor 5 -2.811
C5 complement component 5 -2.74543
FBXL12 F-box and leucine-rich repeat protein 12 -2.687
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.59738
GNAS GNAS complex locus -2.50127
TLR4 toll-like receptor 4 -2.44716
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.44118
PROS1 protein S (alpha) -2.43183
WASHC4 WASH complex subunit 4 -2.43169
TLCD3A TLC domain containing 3A -2.42299
NLRP4 NLR family, pyrin domain containing 4 -2.1993
PRAF2 PRA1 domain family, member 2 -2.1981
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.14642
HP1BP3 heterochromatin protein 1, binding protein 3 -2.02653