CRCGN010_HEPG2_24H:D09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethanolamine 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

243 genes differentially expressed following the CRCGN010_HEPG2_24H:D09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 8.23225
CXCL2 chemokine (C-X-C motif) ligand 2 8.09618
KCNK1 potassium channel, two pore domain subfamily K, member 1 6.98861
LCN2 lipocalin 2 6.87333
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.26643
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 6.21758
OXCT1 3-oxoacid CoA transferase 1 6.1775
GSTZ1 glutathione S-transferase zeta 1 5.57494
CHN1 chimerin 1 5.39121
CRTAP cartilage associated protein 5.19695
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 5.07866
HOXA10 homeobox A10 4.72388
EDN1 endothelin 1 4.68349
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.60746
NOTCH1 notch 1 4.51988
CCNA1 cyclin A1 4.48187
DHDDS dehydrodolichyl diphosphate synthase 4.38694
FZD7 frizzled class receptor 7 4.30458
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.30399
KIFBP kinesin family binding protein 4.27338
INSIG1 insulin induced gene 1 4.22281
PEX11A peroxisomal biogenesis factor 11 alpha 4.20798
LPAR2 lysophosphatidic acid receptor 2 4.19088
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.15849
STAP2 signal transducing adaptor family member 2 4.11359
GPER1 G protein-coupled estrogen receptor 1 3.99683
ADGRE5 adhesion G protein-coupled receptor E5 3.96274
TRAM2 translocation associated membrane protein 2 3.96084
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.93086
PARP1 poly (ADP-ribose) polymerase 1 3.90895
SYNE2 spectrin repeat containing, nuclear envelope 2 3.8719
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.80059
CDK6 cyclin-dependent kinase 6 3.76075
NPIPB6 nuclear pore complex interacting protein family, member B6 3.74775
GATA3 GATA binding protein 3 3.5141
MAMLD1 mastermind-like domain containing 1 3.38162
MYLK myosin light chain kinase 3.28684
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.20892
EVL Enah/Vasp-like 3.13749
LOXL1 lysyl oxidase-like 1 3.10042
VGLL4 vestigial-like family member 4 3.06398
TIAM1 T-cell lymphoma invasion and metastasis 1 3.02259
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.01782
PRR15L proline rich 15-like 2.95112
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.94426
PLS1 plastin 1 2.93374
PRKCH protein kinase C, eta 2.87103
ANKRD10 ankyrin repeat domain 10 2.8709
GPN2 GPN-loop GTPase 2 2.78702
KDM5A lysine (K)-specific demethylase 5A 2.76308
EAPP E2F-associated phosphoprotein 2.70685
RASA4B RAS p21 protein activator 4B 2.67417
FPGS folylpolyglutamate synthase 2.65352
PLSCR3 phospholipid scramblase 3 2.64025
BAHCC1 BAH domain and coiled-coil containing 1 2.59452
CST5 cystatin D 2.58882
EDNRA endothelin receptor type A 2.5582
DYNLT3 dynein, light chain, Tctex-type 3 2.55516
RPL39L ribosomal protein L39-like 2.55466
LOC128966597 MAL-like protein 2.55084
CTSL cathepsin L 2.54778
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.54304
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.53481
TPD52L2 tumor protein D52-like 2 2.52963
GGTLC1 gamma-glutamyltransferase light chain 1 2.50867
MTM1 myotubularin 1 2.50377
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 2.48896
MCTP2 multiple C2 domains, transmembrane 2 2.44571
CD96 CD96 molecule 2.44282
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.42554
E2F2 E2F transcription factor 2 2.42139
USB1 U6 snRNA biogenesis 1 2.41467
SNX7 sorting nexin 7 2.3745
MMP3 matrix metallopeptidase 3 2.37024
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.35767
HLA-DMA major histocompatibility complex, class II, DM alpha 2.35114
TMEM120B transmembrane protein 120B 2.35039
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.34567
PLSCR1 phospholipid scramblase 1 2.34543
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.33991
CYCS cytochrome c, somatic 2.33751
PDLIM1 PDZ and LIM domain 1 2.32295
ADRB2 adrenoceptor beta 2, surface 2.31944
GRWD1 glutamate-rich WD repeat containing 1 2.31618
CA7 carbonic anhydrase VII 2.30412
TEX10 testis expressed 10 2.30157
RBM15B RNA binding motif protein 15B 2.30043
PARP16 poly (ADP-ribose) polymerase family, member 16 2.28892
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.27542
COPS7A COP9 signalosome subunit 7A 2.26774
TARP TCR gamma alternate reading frame protein 2.26682
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.25492
TBP TATA box binding protein 2.25447
GNLY granulysin 2.24497
XYLT2 xylosyltransferase II 2.24324
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.23977
GARRE1 granule associated Rac and RHOG effector 1 2.23267
TRIM66 tripartite motif containing 66 2.22925
TDP1 tyrosyl-DNA phosphodiesterase 1 2.22258
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.21285
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.2096
HTN3 histatin 3 2.20887
LDAF1 lipid droplet assembly factor 1 2.20721
ZFYVE21 zinc finger, FYVE domain containing 21 2.19889
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.1964
SH3D19 SH3 domain containing 19 2.18095
ZBTB24 zinc finger and BTB domain containing 24 2.18009
IL2RG interleukin 2 receptor, gamma 2.1761
PARP11 poly (ADP-ribose) polymerase family, member 11 2.17535
OSR2 odd-skipped related transciption factor 2 2.16758
CD38 CD38 molecule 2.15904
ARHGAP5 Rho GTPase activating protein 5 2.15571
RBM12B RNA binding motif protein 12B 2.15185
ZBTB25 zinc finger and BTB domain containing 25 2.1433
LOC100652777 group 10 secretory phospholipase A2-like 2.14192
CAPN1 calpain 1, (mu/I) large subunit 2.14094
ACTL7B actin-like 7B 2.12627
DRD4 dopamine receptor D4 2.12477
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.1226
PAX9 paired box 9 2.11924
COL13A1 collagen, type XIII, alpha 1 2.11509
TRH thyrotropin-releasing hormone 2.1124
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.10912
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.10782
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.10339
KLF2 Kruppel-like factor 2 2.0967
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.09465
TBPL1 TBP-like 1 2.09323
PVRIG poliovirus receptor related immunoglobulin domain containing 2.09089
LOC124900275 extensin-like 2.08983
CD7 CD7 molecule 2.08467
TBX21 T-box 21 2.07504
SMR3B submaxillary gland androgen regulated protein 3B 2.07492
TWIST1 twist family bHLH transcription factor 1 2.07324
S100PBP S100P binding protein 2.05884
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.05516
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.04392
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.04042
OXCT2 3-oxoacid CoA transferase 2 2.03825
TBL1Y transducin (beta)-like 1, Y-linked 2.03741
PRMT7 protein arginine methyltransferase 7 2.03728
PEX13 peroxisomal biogenesis factor 13 2.03335
HLA-DRA major histocompatibility complex, class II, DR alpha 2.03103
PSG6 pregnancy specific beta-1-glycoprotein 6 2.02248
TCIM transcriptional and immune response regulator 2.0115
SPAG1 sperm associated antigen 1 2.008
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.00534
COL6A3 collagen, type VI, alpha 3 2.00238
IL3RA interleukin 3 receptor, alpha (low affinity) 2.00093

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -7.10802
NGRN neugrin, neurite outgrowth associated -7.02207
GTPBP8 GTP-binding protein 8 (putative) -6.05163
PCNA proliferating cell nuclear antigen -5.98635
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.45503
TMEM109 transmembrane protein 109 -5.4474
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.34131
CAB39 calcium binding protein 39 -5.27037
YME1L1 YME1-like 1 ATPase -4.6002
TCTN1 tectonic family member 1 -4.58605
LOC124907782 dual specificity protein phosphatase 22 -4.51535
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.28788
GNAS GNAS complex locus -4.03055
TLCD3A TLC domain containing 3A -3.99316
TRIB3 tribbles pseudokinase 3 -3.86924
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.86893
CDC20 cell division cycle 20 -3.79836
PUF60 poly-U binding splicing factor 60KDa -3.65207
ZMIZ1 zinc finger, MIZ-type containing 1 -3.59153
EIF5 eukaryotic translation initiation factor 5 -3.4525
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.4262
MRPS2 mitochondrial ribosomal protein S2 -3.41263
UBE3C ubiquitin protein ligase E3C -3.40858
ADI1 acireductone dioxygenase 1 -3.31015
CHIC2 cysteine-rich hydrophobic domain 2 -3.29573
NRIP1 nuclear receptor interacting protein 1 -3.28703
VAT1 vesicle amine transport 1 -3.28608
OXA1L oxidase (cytochrome c) assembly 1-like -3.26177
CCNB1 cyclin B1 -3.16823
NUP93 nucleoporin 93kDa -3.15688
GOLT1B golgi transport 1B -3.09847
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.08471
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.0829
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.08287
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.9895
ZDHHC6 zinc finger, DHHC-type containing 6 -2.95363
CCDC86 coiled-coil domain containing 86 -2.9509
DNM1L dynamin 1-like -2.91895
SCRIB scribbled planar cell polarity protein -2.90369
RNF167 ring finger protein 167 -2.85617
ITGB1BP1 integrin beta 1 binding protein 1 -2.76
CTNND1 catenin (cadherin-associated protein), delta 1 -2.67339
CHMP4B charged multivesicular body protein 4B -2.6666
MVP major vault protein -2.57125
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.55001
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.48703
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.4768
NXT1 nuclear transport factor 2-like export factor 1 -2.46027
PLK1 polo-like kinase 1 -2.45341
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.42449
FBXL12 F-box and leucine-rich repeat protein 12 -2.42244
LAP3 leucine aminopeptidase 3 -2.37738
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.32413
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.3181
MKKS McKusick-Kaufman syndrome -2.29483
CDC25B cell division cycle 25B -2.29254
ZNF580 zinc finger protein 580 -2.26919
LRRC2 leucine rich repeat containing 2 -2.25206
EIPR1 EARP complex and GARP complex interacting protein 1 -2.23927
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.22827
CD58 CD58 molecule -2.22213
RIOX2 ribosomal oxygenase 2 -2.21985
NRDC nardilysin convertase -2.21182
TLR4 toll-like receptor 4 -2.20726
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.19021
NOL11 nucleolar protein 11 -2.18226
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.18202
NES nestin -2.18079
GTF2IRD1 GTF2I repeat domain containing 1 -2.17279
NOP56 NOP56 ribonucleoprotein -2.17173
TGFB3 transforming growth factor, beta 3 -2.16789
MYL12B myosin, light chain 12B, regulatory -2.16255
MYL9 myosin, light chain 9, regulatory -2.15003
ADORA2B adenosine A2b receptor -2.14573
HPCAL1 hippocalcin-like 1 -2.13074
TOMM70 translocase of outer mitochondrial membrane 70 -2.13057
PRKCD protein kinase C, delta -2.12776
MTA1 metastasis associated 1 -2.11907
MAPK13 mitogen-activated protein kinase 13 -2.11543
GABARAP GABA(A) receptor-associated protein -2.1121
MRPL58 mitochondrial ribosomal protein L58 -2.10795
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.10763
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.09721
RPS5 ribosomal protein S5 -2.06244
PLAT plasminogen activator, tissue -2.05883
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.05269
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.05063
TRIM44 tripartite motif containing 44 -2.0478
ARID5B AT rich interactive domain 5B (MRF1-like) -2.02451
NCOA6 nuclear receptor coactivator 6 -2.02243
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.01938
PRPF19 pre-mRNA processing factor 19 -2.00947
PDZD2 PDZ domain containing 2 -2.00925
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.00364