CRCGN010_HEPG2_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethanolamine 4.93 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN010_HEPG2_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 5.27457
NOTCH1 notch 1 5.25107
STIMATE STIM activating enhancer 4.57415
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.42878
MAP7 microtubule-associated protein 7 4.41921
ADGRE5 adhesion G protein-coupled receptor E5 4.28633
LAGE3 L antigen family, member 3 3.73274
CHN1 chimerin 1 3.4693
TIAM1 T-cell lymphoma invasion and metastasis 1 3.43837
LCN2 lipocalin 2 3.16496
SFTPB surfactant protein B 3.04671
INTS3 integrator complex subunit 3 2.91209
PNKP polynucleotide kinase 3'-phosphatase 2.9002
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.89601
CSK c-src tyrosine kinase 2.87118
KLHL21 kelch-like family member 21 2.82581
MYLK myosin light chain kinase 2.55963
LOC122526780 uncharacterized LOC122526780 2.44298
RAB21 RAB21, member RAS oncogene family 2.40432
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.38363
MCM3 minichromosome maintenance complex component 3 2.3522
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.31739
GADD45A growth arrest and DNA-damage-inducible, alpha 2.17238
CCNH cyclin H 2.15402
HEATR3 HEAT repeat containing 3 2.11422
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.10628
PFKL phosphofructokinase, liver 2.07742
GSTZ1 glutathione S-transferase zeta 1 2.06069
GATA2 GATA binding protein 2 2.05468
GALT galactose-1-phosphate uridylyltransferase 2.01337

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.31799
CCNB2 cyclin B2 -7.31766
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.69756
OXA1L oxidase (cytochrome c) assembly 1-like -3.60363
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.47274
GNAS GNAS complex locus -3.44112
PRPF4 pre-mRNA processing factor 4 -3.11143
DNM1L dynamin 1-like -3.01052
LDHD lactate dehydrogenase D -2.89649
KDM3A lysine (K)-specific demethylase 3A -2.5251
TLR4 toll-like receptor 4 -2.46639
WASHC4 WASH complex subunit 4 -2.37819
TRIB3 tribbles pseudokinase 3 -2.35688
NRIP1 nuclear receptor interacting protein 1 -2.25236
TLCD3A TLC domain containing 3A -2.18655