CRCGN010_HEPG2_24H:D12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethanolamine 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN010_HEPG2_24H:D12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.27602
STIMATE STIM activating enhancer 5.17994
UBQLN2 ubiquilin 2 4.99068
PPARG peroxisome proliferator-activated receptor gamma 4.62858
AMDHD2 amidohydrolase domain containing 2 4.44762
CXCR4 chemokine (C-X-C motif) receptor 4 4.41112
E2F2 E2F transcription factor 2 4.31467
ADGRE5 adhesion G protein-coupled receptor E5 4.26927
EVL Enah/Vasp-like 4.08302
IDE insulin-degrading enzyme 3.6424
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.63109
GSTZ1 glutathione S-transferase zeta 1 3.62791
DENND2D DENN/MADD domain containing 2D 3.60363
PLSCR1 phospholipid scramblase 1 3.52713
CCL2 chemokine (C-C motif) ligand 2 3.51187
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.41595
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.23599
HSPA1A heat shock 70kDa protein 1A 3.18503
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.02835
LPAR2 lysophosphatidic acid receptor 2 2.66901
CEMIP2 cell migration inducing hyaluronidase 2 2.46301
GATA2 GATA binding protein 2 2.31358
LCN2 lipocalin 2 2.29456
GTPBP6 GTP binding protein 6 (putative) 2.2151
NADSYN1 NAD synthetase 1 2.15071
CXCL2 chemokine (C-X-C motif) ligand 2 2.13336
STXBP2 syntaxin binding protein 2 2.11084
RAB31 RAB31, member RAS oncogene family 2.08407
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.0832
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.03658
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.00527
CD1C CD1c molecule 2.0039

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -8.63711
MRPS2 mitochondrial ribosomal protein S2 -6.72727
TLR4 toll-like receptor 4 -6.38541
TSPAN4 tetraspanin 4 -4.7863
CCDC86 coiled-coil domain containing 86 -4.78198
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.71565
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.6145
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.56145
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.23515
PCNA proliferating cell nuclear antigen -4.03066
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.92033
SLC35F2 solute carrier family 35, member F2 -3.82769
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.67886
SNX11 sorting nexin 11 -3.6602
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.58459
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.46663
GNAS GNAS complex locus -3.36923
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.00491
HMG20B high mobility group 20B -2.8458
FGFR4 fibroblast growth factor receptor 4 -2.82523
RBM34 RNA binding motif protein 34 -2.63942
CST5 cystatin D -2.5542
MAPK13 mitogen-activated protein kinase 13 -2.52978
RHOBTB2 Rho-related BTB domain containing 2 -2.41287
PLA2G15 phospholipase A2, group XV -2.34306
FAT1 FAT atypical cadherin 1 -2.29234
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.24105
PLCB4 phospholipase C, beta 4 -2.23596
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.2258
PEA15 phosphoprotein enriched in astrocytes 15 -2.21562
MFGE8 milk fat globule-EGF factor 8 protein -2.19273
SCCPDH saccharopine dehydrogenase (putative) -2.19062
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.16394
STAT1 signal transducer and activator of transcription 1, 91kDa -2.15947
PPOX protoporphyrinogen oxidase -2.14236
KIAA0319L KIAA0319-like -2.13509
MAST4 microtubule associated serine/threonine kinase family member 4 -2.11447
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.10294
TMT1A thiol methyltransferase 1A -2.09658
TP53BP2 tumor protein p53 binding protein 2 -2.04649
CLDN16 claudin 16 -2.03735
SH2B2 SH2B adaptor protein 2 -2.02799
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.02471
CPNE3 copine III -2.013