CRCGN010_HEPG2_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dioxane 20.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

68 genes differentially expressed following the CRCGN010_HEPG2_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 6.28627
LCN2 lipocalin 2 5.76135
MAP7 microtubule-associated protein 7 4.5182
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.93849
CXCL2 chemokine (C-X-C motif) ligand 2 3.72727
CSK c-src tyrosine kinase 3.60029
MBTPS1 membrane-bound transcription factor peptidase, site 1 3.48554
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.38052
STIMATE STIM activating enhancer 3.29099
EVL Enah/Vasp-like 3.10751
DYNLT3 dynein, light chain, Tctex-type 3 3.02909
DIPK1A divergent protein kinase domain 1A 2.87021
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.86787
PRR15L proline rich 15-like 2.77271
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.64322
RBKS ribokinase 2.58205
HMOX1 heme oxygenase 1 2.54406
PLSCR3 phospholipid scramblase 3 2.48958
CEP57 centrosomal protein 57kDa 2.39664
VRK2 vaccinia related kinase 2 2.37194
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.35404
PPARG peroxisome proliferator-activated receptor gamma 2.26553
STXBP2 syntaxin binding protein 2 2.20845
UBE2A ubiquitin-conjugating enzyme E2A 2.16861
MCUR1 mitochondrial calcium uniporter regulator 1 2.1612
MARCKSL1 MARCKS-like 1 2.13893
BBOF1 basal body orientation factor 1 2.1323
SPATS2 spermatogenesis associated, serine-rich 2 2.12861
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.09901
RPA3 replication protein A3, 14kDa 2.0691

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.95467
TLR4 toll-like receptor 4 -5.1607
SLC35F2 solute carrier family 35, member F2 -4.75232
KDM3A lysine (K)-specific demethylase 3A -4.34779
MAPK13 mitogen-activated protein kinase 13 -4.0576
PCNA proliferating cell nuclear antigen -3.70487
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.54898
NUP85 nucleoporin 85kDa -3.38583
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.35197
OXA1L oxidase (cytochrome c) assembly 1-like -3.3381
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.16077
ZNF274 zinc finger protein 274 -3.11395
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.98148
TXNRD1 thioredoxin reductase 1 -2.8953
ZNF586 zinc finger protein 586 -2.84816
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.83904
TRAPPC3 trafficking protein particle complex 3 -2.83719
RNF167 ring finger protein 167 -2.83581
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.58837
ZDHHC6 zinc finger, DHHC-type containing 6 -2.45133
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.40177
LOXL1 lysyl oxidase-like 1 -2.37927
MED31 mediator complex subunit 31 -2.32263
TMEM94 transmembrane protein 94 -2.26888
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.26755
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.23619
KANSL3 KAT8 regulatory NSL complex subunit 3 -2.20286
TRIB3 tribbles pseudokinase 3 -2.20099
CAMK1 calcium/calmodulin-dependent protein kinase I -2.11566
LCE2B late cornified envelope 2B -2.08547
LIM2 lens intrinsic membrane protein 2, 19kDa -2.08351
ADAM9 ADAM metallopeptidase domain 9 -2.08343
KPLCE KPRP N-terminal and LCE C-terminal like protein -2.07778
H3-4 H3.4 histone, cluster member -2.07166
ZFR2 zinc finger RNA binding protein 2 -2.05065
ZNF780A zinc finger protein 780A -2.04173
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.03751
NCKAP1 NCK-associated protein 1 -2.00826