CRCGN010_HEPG2_24H:D15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dioxane 10.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN010_HEPG2_24H:D15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 6.63581
ZFP36 ZFP36 ring finger protein 5.28974
CSK c-src tyrosine kinase 5.08727
UBQLN2 ubiquilin 2 5.07882
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.49135
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.44797
KLHL21 kelch-like family member 21 4.36964
CEMIP2 cell migration inducing hyaluronidase 2 3.90995
GATA3 GATA binding protein 3 3.55677
MELK maternal embryonic leucine zipper kinase 3.47906
HLA-DRA major histocompatibility complex, class II, DR alpha 2.92213
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.78343
SLC38A6 solute carrier family 38, member 6 2.78267
DMTF1 cyclin D binding myb-like transcription factor 1 2.74697
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.72845
NUP133 nucleoporin 133kDa 2.67702
PDLIM1 PDZ and LIM domain 1 2.67631
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.59261
ZNF589 zinc finger protein 589 2.58158
PRKCH protein kinase C, eta 2.55735
DIPK1A divergent protein kinase domain 1A 2.50534
GCFC2 GC-rich sequence DNA-binding factor 2 2.43666
ZNF518A zinc finger protein 518A 2.35849
MSRA methionine sulfoxide reductase A 2.33653
FGGY FGGY carbohydrate kinase domain containing 2.33421
LIME1 Lck interacting transmembrane adaptor 1 2.26985
WDR47 WD repeat domain 47 2.25457
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.22668
DYNLT3 dynein, light chain, Tctex-type 3 2.22013
EMC2 ER membrane protein complex subunit 2 2.13984
WFS1 Wolfram syndrome 1 (wolframin) 2.11528
RPAP3 RNA polymerase II associated protein 3 2.08485
IPO4 importin 4 2.07179
MCUR1 mitochondrial calcium uniporter regulator 1 2.05805
DPY19L4 dpy-19-like 4 (C. elegans) 2.04946
MTERF3 mitochondrial transcription termination factor 3 2.04753
THAP11 THAP domain containing 11 2.01232
FAIM Fas apoptotic inhibitory molecule 2.01005

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.13407
GNAS GNAS complex locus -6.71068
PCNA proliferating cell nuclear antigen -5.07859
ZNF586 zinc finger protein 586 -4.65151
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.60236
CCDC86 coiled-coil domain containing 86 -4.03304
CD320 CD320 molecule -3.99781
ZDHHC6 zinc finger, DHHC-type containing 6 -3.75576
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.6349
VDAC1 voltage-dependent anion channel 1 -3.49346
NUP85 nucleoporin 85kDa -3.4643
VAT1 vesicle amine transport 1 -3.33
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.32932
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.20926
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.19921
NRIP1 nuclear receptor interacting protein 1 -2.93882
SUMO4 small ubiquitin-like modifier 4 -2.89924
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.62832
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.60443
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.53749
NACAD NAC alpha domain containing -2.50301
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -2.40932
COX7B cytochrome c oxidase subunit VIIb -2.35238
VBP1 von Hippel-Lindau binding protein 1 -2.33609
TMEM242 transmembrane protein 242 -2.32263
PDZD2 PDZ domain containing 2 -2.31393
OLFM4 olfactomedin 4 -2.28919
LYPLA1 lysophospholipase I -2.2846
MTMR10 myotubularin related protein 10 -2.27543
CPNE6 copine VI (neuronal) -2.24911
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.24164
KCTD2 potassium channel tetramerization domain containing 2 -2.2414
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.22047
YJU2 YJU2 splicing factor homolog -2.19437
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -2.18013
WSCD1 WSC domain containing 1 -2.17837
CDHR2 cadherin-related family member 2 -2.17785
DUSP28 dual specificity phosphatase 28 -2.17595
CRYBB1 crystallin, beta B1 -2.16409
MYO1A myosin IA -2.14278
SCTR secretin receptor -2.11435
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.11113
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.10515
TMSB15C thymosin beta 15C -2.09755
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -2.09221
DNASE1L1 deoxyribonuclease I-like 1 -2.08458
ZNF219 zinc finger protein 219 -2.08262
PPOX protoporphyrinogen oxidase -2.08147
HSPA8 heat shock 70kDa protein 8 -2.08081
ATP5PD ATP synthase peripheral stalk subunit d -2.07603
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.07249
CCDC177 coiled-coil domain containing 177 -2.05468
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.04591
ACTL6B actin-like 6B -2.03898
CXADR coxsackie virus and adenovirus receptor -2.01981
XAB2 XPA binding protein 2 -2.01515
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.01316
AMHR2 anti-Mullerian hormone receptor, type II -2.00783
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.00242
MMP24 matrix metallopeptidase 24 (membrane-inserted) -2.00186