CRCGN010_HEPG2_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1,3-dichloro-2-propyl) phosphate 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN010_HEPG2_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MOK MOK protein kinase 5.41817
SRC SRC proto-oncogene, non-receptor tyrosine kinase 5.11876
MYLK myosin light chain kinase 5.0965
STIMATE STIM activating enhancer 5.06384
CHMP6 charged multivesicular body protein 6 4.78736
EVL Enah/Vasp-like 4.58935
RPP38 ribonuclease P/MRP 38kDa subunit 4.05898
LOC122526780 uncharacterized LOC122526780 4.04079
CIAO3 cytosolic iron-sulfur assembly component 3 4.01119
BACE2 beta-site APP-cleaving enzyme 2 3.84141
PPARG peroxisome proliferator-activated receptor gamma 3.72774
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.56977
PRKCH protein kinase C, eta 3.45372
PEX11A peroxisomal biogenesis factor 11 alpha 3.30998
NOSIP nitric oxide synthase interacting protein 3.15409
GATA3 GATA binding protein 3 2.95384
CYCS cytochrome c, somatic 2.85426
LPAR2 lysophosphatidic acid receptor 2 2.60435
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.49213
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.36048
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.31506
HSPA8 heat shock 70kDa protein 8 2.27325
TFF2 trefoil factor 2 2.04706
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.01276

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.74634
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.19609
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.43117
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.27474
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.21814
CCNB1 cyclin B1 -4.16796
MRPS2 mitochondrial ribosomal protein S2 -4.08619
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.97741
PCNA proliferating cell nuclear antigen -3.63496
ZNF586 zinc finger protein 586 -3.30603
CAPNS1 calpain, small subunit 1 -2.5819
PEG10 paternally expressed 10 -2.5123
AURKB aurora kinase B -2.45851
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.34349
TLCD3A TLC domain containing 3A -2.2604
SNRPF small nuclear ribonucleoprotein polypeptide F -2.18287
LOC124907782 dual specificity protein phosphatase 22 -2.05657
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.00108
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.0