CRCGN010_HEPG2_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 21.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN010_HEPG2_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.75949
CXCL2 chemokine (C-X-C motif) ligand 2 4.17155
MAP7 microtubule-associated protein 7 4.11062
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.90397
LCN2 lipocalin 2 3.68524
C2CD2 C2 calcium-dependent domain containing 2 3.53172
AMDHD2 amidohydrolase domain containing 2 3.2687
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.18209
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.17471
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.08273
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.99137
CARMIL1 capping protein regulator and myosin 1 linker 1 2.98544
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.94334
NUCB2 nucleobindin 2 2.90343
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.82629
TENT4A terminal nucleotidyltransferase 4A 2.5571
DIPK1A divergent protein kinase domain 1A 2.44776
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.05563
MEST mesoderm specific transcript 2.04691
UGDH UDP-glucose 6-dehydrogenase 2.03447

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -8.01461
ZNF586 zinc finger protein 586 -5.95058
C2CD5 C2 calcium-dependent domain containing 5 -4.68005
FBXL12 F-box and leucine-rich repeat protein 12 -4.23624
OXA1L oxidase (cytochrome c) assembly 1-like -4.17934
HAT1 histone acetyltransferase 1 -3.94152
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.31002
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.86873
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.81589
TLCD3A TLC domain containing 3A -2.72426
PECR peroxisomal trans-2-enoyl-CoA reductase -2.63347
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.56495
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.46189
LDHD lactate dehydrogenase D -2.4237
RPS5 ribosomal protein S5 -2.35304
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.2964
SLC75A1 solute carrier family 75 member 1 -2.26633
DDIT4 DNA-damage-inducible transcript 4 -2.16027
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.05772
FBXO3 F-box protein 3 -2.05061
GASK1B golgi associated kinase 1B -2.02036