CRCGN010_HEPG2_24H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 10.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

77 genes differentially expressed following the CRCGN010_HEPG2_24H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.32011
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.7938
GSTZ1 glutathione S-transferase zeta 1 5.03787
STK10 serine/threonine kinase 10 4.98278
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.88729
LYN LYN proto-oncogene, Src family tyrosine kinase 4.54577
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.49508
EPHB2 EPH receptor B2 4.43995
CYCS cytochrome c, somatic 4.30421
MAP7 microtubule-associated protein 7 4.03695
VAV3 vav 3 guanine nucleotide exchange factor 3.80871
MCM3 minichromosome maintenance complex component 3 3.71023
HOXA10 homeobox A10 3.60581
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.49345
TENT4A terminal nucleotidyltransferase 4A 3.49175
PMM2 phosphomannomutase 2 3.41141
CHN1 chimerin 1 3.30832
AXIN1 axin 1 3.30161
PRKCH protein kinase C, eta 2.88362
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.7702
EVL Enah/Vasp-like 2.73347
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.69748
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.67549
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.60361
GPATCH8 G patch domain containing 8 2.45506
H2BC21 H2B clustered histone 21 2.43396
PLS1 plastin 1 2.41017
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.2572
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.20387
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.19277
GLI3 GLI family zinc finger 3 2.14912
YBX2 Y box binding protein 2 2.13602
APOBR apolipoprotein B receptor 2.12233
GSTCD glutathione S-transferase, C-terminal domain containing 2.1208
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.11747
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.07925
RBM12B RNA binding motif protein 12B 2.07405
DGKD diacylglycerol kinase, delta 130kDa 2.07087
BEST2 bestrophin 2 2.06413
PLA2G12A phospholipase A2, group XIIA 2.04021
RIPPLY3 ripply transcriptional repressor 3 2.03484
NXPH4 neurexophilin 4 2.0246
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.01857
SATB2 SATB homeobox 2 2.0111
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.00954

decreased expression

Symbol Name Standardized Value
ZDHHC6 zinc finger, DHHC-type containing 6 -5.0374
ACOT9 acyl-CoA thioesterase 9 -4.95919
VAT1 vesicle amine transport 1 -4.9387
KDM3A lysine (K)-specific demethylase 3A -4.92437
TLR4 toll-like receptor 4 -4.88948
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.87346
C2CD5 C2 calcium-dependent domain containing 5 -4.85715
ZNF586 zinc finger protein 586 -4.62942
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.60354
ITGB1BP1 integrin beta 1 binding protein 1 -4.51242
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.48403
LDHD lactate dehydrogenase D -4.23062
CCNB2 cyclin B2 -4.08655
FBXL12 F-box and leucine-rich repeat protein 12 -3.99517
CD58 CD58 molecule -3.90246
MAPK13 mitogen-activated protein kinase 13 -3.67069
SNX11 sorting nexin 11 -3.54307
SLC35F2 solute carrier family 35, member F2 -2.95145
YME1L1 YME1-like 1 ATPase -2.76005
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.52691
DCK deoxycytidine kinase -2.40521
COMMD3 COMM domain containing 3 -2.39081
RGS2 regulator of G-protein signaling 2 -2.38857
EIF5 eukaryotic translation initiation factor 5 -2.32048
RNF167 ring finger protein 167 -2.21146
RPS5 ribosomal protein S5 -2.18882
GPN1 GPN-loop GTPase 1 -2.17693
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.16197
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.14004
WASHC4 WASH complex subunit 4 -2.08642
TFF2 trefoil factor 2 -2.03802
KAT7 K(lysine) acetyltransferase 7 -2.02956