CRCGN010_HEPG2_24H:E03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 5.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN010_HEPG2_24H:E03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.7417
AMDHD2 amidohydrolase domain containing 2 5.95058
CHN1 chimerin 1 5.41695
CIAO3 cytosolic iron-sulfur assembly component 3 5.14112
CXCL2 chemokine (C-X-C motif) ligand 2 5.12005
E2F2 E2F transcription factor 2 5.05911
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.76602
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.74648
ADRB2 adrenoceptor beta 2, surface 4.74305
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.53729
TREM1 triggering receptor expressed on myeloid cells 1 4.52779
MAP7 microtubule-associated protein 7 4.11744
MYLK myosin light chain kinase 3.95722
LCN2 lipocalin 2 3.94005
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.93774
GPER1 G protein-coupled estrogen receptor 1 3.79114
RRAGA Ras-related GTP binding A 3.25861
PRKCH protein kinase C, eta 3.2385
VGLL4 vestigial-like family member 4 3.19785
SSBP2 single-stranded DNA binding protein 2 3.00612
JADE2 jade family PHD finger 2 2.98827
COPS7A COP9 signalosome subunit 7A 2.57933
MEST mesoderm specific transcript 2.5654
DIPK1A divergent protein kinase domain 1A 2.4126
FZD1 frizzled class receptor 1 2.33112
SH3D19 SH3 domain containing 19 2.2609
ZFP36 ZFP36 ring finger protein 2.25382
PLSCR3 phospholipid scramblase 3 2.19097
GLI3 GLI family zinc finger 3 2.05945
SART3 squamous cell carcinoma antigen recognized by T cells 3 2.05634
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.03554
HSPA1A heat shock 70kDa protein 1A 2.02951
KYAT1 kynurenine aminotransferase 1 2.02694
BCR breakpoint cluster region 2.0222
ZBTB35 zinc finger and BTB domain containing 35 2.01489

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.6908
TLR4 toll-like receptor 4 -6.44732
TCTN1 tectonic family member 1 -5.4164
CCNB2 cyclin B2 -5.40159
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.92583
ADI1 acireductone dioxygenase 1 -4.88103
CAB39 calcium binding protein 39 -4.84727
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.84492
CD320 CD320 molecule -4.75177
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.69214
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.61524
CTNND1 catenin (cadherin-associated protein), delta 1 -4.52461
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.22454
KDM3A lysine (K)-specific demethylase 3A -4.1481
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.96195
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.94781
CCDC86 coiled-coil domain containing 86 -3.92565
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.90374
RNF167 ring finger protein 167 -3.9031
GNAS GNAS complex locus -3.79992
MAPK13 mitogen-activated protein kinase 13 -3.72784
ZNF586 zinc finger protein 586 -3.68932
NUP85 nucleoporin 85kDa -3.56652
SLIRP SRA stem-loop interacting RNA binding protein -3.37674
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.1245
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.04295
MTA1 metastasis associated 1 -2.91779
TSG101 tumor susceptibility 101 -2.77789
MRPS7 mitochondrial ribosomal protein S7 -2.76421
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.52903
DDIT4 DNA-damage-inducible transcript 4 -2.50487
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.46217
FBXL12 F-box and leucine-rich repeat protein 12 -2.39344
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.34635
EIF5 eukaryotic translation initiation factor 5 -2.3386
TRIP4 thyroid hormone receptor interactor 4 -2.23434
UBL5 ubiquitin-like 5 -2.22832
RPS5 ribosomal protein S5 -2.19975
RPL26L1 ribosomal protein L26-like 1 -2.14355
MRPL40 mitochondrial ribosomal protein L40 -2.0904
TBCB tubulin folding cofactor B -2.08477
ATP5PD ATP synthase peripheral stalk subunit d -2.07751
GLOD4 glyoxalase domain containing 4 -2.07636
USP6NL USP6 N-terminal like -2.07516
PSENEN presenilin enhancer gamma secretase subunit -2.055
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.04501
JPT1 Jupiter microtubule associated homolog 1 -2.04302
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.02201
CALML4 calmodulin-like 4 -2.01222
RPL38 ribosomal protein L38 -2.00023