| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 2.65 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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70 genes differentially expressed following the CRCGN010_HEPG2_24H:E04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.38904 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.20878 |
| EVL | Enah/Vasp-like | 5.03502 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.74005 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.71854 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.64819 |
| E2F2 | E2F transcription factor 2 | 4.52366 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.44031 |
| STK10 | serine/threonine kinase 10 | 4.22092 |
| MOK | MOK protein kinase | 4.19029 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.16117 |
| RRAGA | Ras-related GTP binding A | 4.0504 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.91726 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 3.91014 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.62942 |
| EPN2 | epsin 2 | 3.59548 |
| BLMH | bleomycin hydrolase | 3.404 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.27682 |
| CEP57 | centrosomal protein 57kDa | 3.25303 |
| PLS1 | plastin 1 | 3.21522 |
| MEST | mesoderm specific transcript | 3.19573 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.02032 |
| GATA3 | GATA binding protein 3 | 2.91553 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.8139 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 2.64982 |
| CYCS | cytochrome c, somatic | 2.63165 |
| SH3D19 | SH3 domain containing 19 | 2.36282 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.23133 |
| LRRC32 | leucine rich repeat containing 32 | 2.12193 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.07987 |
| PTK2 | protein tyrosine kinase 2 | 2.05614 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.02173 |
| RAD51AP1 | RAD51 associated protein 1 | 2.00205 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -6.07571 |
| LDHD | lactate dehydrogenase D | -5.35965 |
| DSG2 | desmoglein 2 | -5.15801 |
| ACOT9 | acyl-CoA thioesterase 9 | -4.95793 |
| SLC35F2 | solute carrier family 35, member F2 | -4.62449 |
| UGDH | UDP-glucose 6-dehydrogenase | -4.61829 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -4.52543 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -4.48472 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -4.3996 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.36071 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.31051 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -4.26215 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.19238 |
| CDK4 | cyclin-dependent kinase 4 | -4.03712 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.01102 |
| WASHC4 | WASH complex subunit 4 | -3.2501 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.17918 |
| YME1L1 | YME1-like 1 ATPase | -3.17705 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.94159 |
| TCTN1 | tectonic family member 1 | -2.8206 |
| HEATR1 | HEAT repeat containing 1 | -2.59438 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.57026 |
| GNAS | GNAS complex locus | -2.56789 |
| DCK | deoxycytidine kinase | -2.54602 |
| HMG20B | high mobility group 20B | -2.47832 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | -2.45835 |
| SOAT2 | sterol O-acyltransferase 2 | -2.40467 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.35472 |
| TSFM | Ts translation elongation factor, mitochondrial | -2.30956 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.3028 |
| CCNH | cyclin H | -2.29215 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.25618 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.21349 |
| CAB39 | calcium binding protein 39 | -2.1944 |
| FASTKD5 | FAST kinase domains 5 | -2.1691 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.08872 |
| PRPF4 | pre-mRNA processing factor 4 | -2.05821 |
