| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 20.62 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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110 genes differentially expressed following the CRCGN010_HEPG2_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 7.59406 |
| HOXA10 | homeobox A10 | 6.45938 |
| LCN2 | lipocalin 2 | 6.38337 |
| RRAGA | Ras-related GTP binding A | 5.44002 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 5.12771 |
| PLSCR1 | phospholipid scramblase 1 | 4.84167 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 4.58142 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.45773 |
| LPAR2 | lysophosphatidic acid receptor 2 | 4.37893 |
| CSK | c-src tyrosine kinase | 4.1918 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.01899 |
| PRKCH | protein kinase C, eta | 3.98177 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 3.9101 |
| CYCS | cytochrome c, somatic | 3.89184 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 3.87048 |
| E2F2 | E2F transcription factor 2 | 3.81585 |
| NOTCH1 | notch 1 | 3.80418 |
| OXCT1 | 3-oxoacid CoA transferase 1 | 3.76055 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.74943 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.7445 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.51101 |
| INSIG1 | insulin induced gene 1 | 3.43299 |
| MICALL1 | MICAL-like 1 | 3.24447 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.17312 |
| CCNF | cyclin F | 3.13601 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | 3.12765 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 3.10026 |
| NOSIP | nitric oxide synthase interacting protein | 3.07258 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.99453 |
| STK10 | serine/threonine kinase 10 | 2.9319 |
| EPHA3 | EPH receptor A3 | 2.80948 |
| MMP2 | matrix metallopeptidase 2 | 2.77717 |
| FZD7 | frizzled class receptor 7 | 2.77246 |
| ZNF318 | zinc finger protein 318 | 2.72628 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 2.68943 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 2.68653 |
| HBA1 | hemoglobin, alpha 1 | 2.66284 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.60089 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | 2.57039 |
| SH3D19 | SH3 domain containing 19 | 2.57007 |
| HSPA1A | heat shock 70kDa protein 1A | 2.53643 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 2.45185 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 2.42374 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.42078 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 2.39025 |
| CHMP6 | charged multivesicular body protein 6 | 2.30243 |
| SIPA1 | signal-induced proliferation-associated 1 | 2.28182 |
| TGIF1 | TGFB-induced factor homeobox 1 | 2.27207 |
| CHN1 | chimerin 1 | 2.26535 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 2.25926 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.24341 |
| HOXA11 | homeobox A11 | 2.24205 |
| NUCB2 | nucleobindin 2 | 2.20217 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.19779 |
| EVL | Enah/Vasp-like | 2.18121 |
| EGF | epidermal growth factor | 2.16257 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.11326 |
| LOC122526780 | uncharacterized LOC122526780 | 2.08468 |
| PTBP3 | polypyrimidine tract binding protein 3 | 2.03957 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -7.22992 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -6.16363 |
| CCNB2 | cyclin B2 | -6.11839 |
| TLR4 | toll-like receptor 4 | -4.8243 |
| SLC35F2 | solute carrier family 35, member F2 | -4.0964 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.96794 |
| LOC124907782 | dual specificity protein phosphatase 22 | -3.85959 |
| CHMP4B | charged multivesicular body protein 4B | -3.79252 |
| VAT1 | vesicle amine transport 1 | -3.52505 |
| TCTN1 | tectonic family member 1 | -3.52154 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.32244 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -3.28383 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.26891 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.26024 |
| ADI1 | acireductone dioxygenase 1 | -3.25215 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.22437 |
| LDHD | lactate dehydrogenase D | -3.19981 |
| REEP5 | receptor accessory protein 5 | -3.18301 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.17109 |
| WASHC4 | WASH complex subunit 4 | -3.12826 |
| TLCD3A | TLC domain containing 3A | -3.02764 |
| THAP11 | THAP domain containing 11 | -3.01815 |
| CDC20 | cell division cycle 20 | -2.87239 |
| HEATR1 | HEAT repeat containing 1 | -2.8432 |
| NVL | nuclear VCP-like | -2.79127 |
| CDC25B | cell division cycle 25B | -2.7662 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.70798 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -2.65421 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.61229 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.56036 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.5283 |
| DNALI1 | dynein, axonemal, light intermediate chain 1 | -2.45879 |
| NGRN | neugrin, neurite outgrowth associated | -2.42063 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | -2.40871 |
| PDLIM1 | PDZ and LIM domain 1 | -2.40848 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.36621 |
| CCL13 | chemokine (C-C motif) ligand 13 | -2.33733 |
| ZNF586 | zinc finger protein 586 | -2.32911 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -2.32782 |
| GNPAT | glyceronephosphate O-acyltransferase | -2.29804 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -2.29553 |
| BTBD1 | BTB (POZ) domain containing 1 | -2.29235 |
| LAGE3 | L antigen family, member 3 | -2.26397 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.19464 |
| ZC2HC1A | zinc finger, C2HC-type containing 1A | -2.18894 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | -2.13407 |
| CHEK1 | checkpoint kinase 1 | -2.08492 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.0849 |
| USP3 | ubiquitin specific peptidase 3 | -2.04865 |
| MCOLN1 | mucolipin 1 | -2.04245 |
| LOXL1 | lysyl oxidase-like 1 | -2.02586 |
