CRCGN010_HEPG2_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 2.58 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

71 genes differentially expressed following the CRCGN010_HEPG2_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 7.58076
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 5.59767
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.35312
CXCL2 chemokine (C-X-C motif) ligand 2 5.1581
RPP38 ribonuclease P/MRP 38kDa subunit 4.331
C2CD2 C2 calcium-dependent domain containing 2 4.18047
HDGFL3 HDGF like 3 3.96913
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.92174
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.65625
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.55148
PPARG peroxisome proliferator-activated receptor gamma 3.48512
ZFP36 ZFP36 ring finger protein 3.37438
LPAR2 lysophosphatidic acid receptor 2 3.2079
CRTAP cartilage associated protein 3.17783
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.01827
HSPA1A heat shock 70kDa protein 1A 2.96524
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.65845
TNIP1 TNFAIP3 interacting protein 1 2.6479
OXCT1 3-oxoacid CoA transferase 1 2.47232
CALU calumenin 2.45913
INTS3 integrator complex subunit 3 2.44589
TBC1D10C TBC1 domain family, member 10C 2.42951
NUCB2 nucleobindin 2 2.38314
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.37886
SOCS2 suppressor of cytokine signaling 2 2.2828
RB1 retinoblastoma 1 2.21525
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.11632
STK10 serine/threonine kinase 10 2.08975
CBR3 carbonyl reductase 3 2.08701
FLNA filamin A, alpha 2.07347
UBQLN2 ubiquilin 2 2.06667
MX1 MX dynamin-like GTPase 1 2.01659

decreased expression

Symbol Name Standardized Value
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -7.34296
RPIA ribose 5-phosphate isomerase A -5.8185
PCNA proliferating cell nuclear antigen -5.02667
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.84412
TLCD3A TLC domain containing 3A -4.81804
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.68335
USP6NL USP6 N-terminal like -4.44432
TUBB6 tubulin, beta 6 class V -4.39275
GNAS GNAS complex locus -4.35308
ARID5B AT rich interactive domain 5B (MRF1-like) -3.98381
ZNF586 zinc finger protein 586 -3.93552
THAP11 THAP domain containing 11 -3.78977
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.40161
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.39632
NGRN neugrin, neurite outgrowth associated -3.18917
CDC20 cell division cycle 20 -3.03587
FAIM Fas apoptotic inhibitory molecule -2.95258
SNX11 sorting nexin 11 -2.81193
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.7857
WASHC4 WASH complex subunit 4 -2.74183
CAB39 calcium binding protein 39 -2.72564
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.68694
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.54034
PDZD2 PDZ domain containing 2 -2.36999
HSPB1 heat shock 27kDa protein 1 -2.31255
NRIP1 nuclear receptor interacting protein 1 -2.29119
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.26554
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.15902
ANKRD36C ankyrin repeat domain 36C -2.15748
MRPL18 mitochondrial ribosomal protein L18 -2.13917
MLYCD malonyl-CoA decarboxylase -2.09656
GTPBP8 GTP-binding protein 8 (putative) -2.07916
VDAC1 voltage-dependent anion channel 1 -2.07098
CD79B CD79b molecule, immunoglobulin-associated beta -2.06935
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.06801
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.03434
CRYGB crystallin, gamma B -2.02813
FOS FBJ murine osteosarcoma viral oncogene homolog -2.01114
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.00127