CRCGN010_HEPG2_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

201 genes differentially expressed following the CRCGN010_HEPG2_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 4.97289
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.32992
CSK c-src tyrosine kinase 3.89801
CYCS cytochrome c, somatic 3.76384
C2CD2 C2 calcium-dependent domain containing 2 3.60588
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.36745
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.36667
MCOLN1 mucolipin 1 3.19209
SATB1 SATB homeobox 1 3.18181
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.12809
GRAMD2B GRAM domain containing 2B 2.94655
SCRN1 secernin 1 2.92306
EFNA3 ephrin-A3 2.8991
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.89647
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.70148
CCDC92 coiled-coil domain containing 92 2.63959
EVL Enah/Vasp-like 2.63382
MAMLD1 mastermind-like domain containing 1 2.61894
FAM131B family with sequence similarity 131, member B 2.5227
CCT8 chaperonin containing TCP1, subunit 8 (theta) 2.49803
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.47819
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.44781
RSF1 remodeling and spacing factor 1 2.44657
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.41289
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.4054
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.40477
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.37328
MOK MOK protein kinase 2.36844
CBR1 carbonyl reductase 1 2.33788
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 2.33487
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.28937
BHMT2 betaine--homocysteine S-methyltransferase 2 2.28422
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.27035
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.2547
WDR7 WD repeat domain 7 2.25342
CNMD chondromodulin 2.25271
USP39 ubiquitin specific peptidase 39 2.24365
TRIM13 tripartite motif containing 13 2.24081
TWSG1 twisted gastrulation BMP signaling modulator 1 2.24003
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.23969
VCAM1 vascular cell adhesion molecule 1 2.23924
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.23691
ADGRE5 adhesion G protein-coupled receptor E5 2.22431
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 2.22396
CMC2 C-x(9)-C motif containing 2 2.21448
CDK6 cyclin-dependent kinase 6 2.21381
CRTAP cartilage associated protein 2.2113
GOLGB1 golgin B1 2.20798
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.20676
CCDC90B coiled-coil domain containing 90B 2.19018
ANO10 anoctamin 10 2.18856
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.1806
NYNRIN NYN domain and retroviral integrase containing 2.17961
CTSL cathepsin L 2.16692
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.16632
IFNG interferon, gamma 2.13636
LOC124904942 uncharacterized LOC124904942 2.13423
SIPA1 signal-induced proliferation-associated 1 2.13137
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.12691
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2.11828
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.11402
FCHO1 FCH domain only 1 2.11361
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.10656
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.10125
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.09969
ZNF260 zinc finger protein 260 2.09862
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.09646
DPH2 DPH2 homolog (S. cerevisiae) 2.09479
KLHL21 kelch-like family member 21 2.09132
CNN1 calponin 1, basic, smooth muscle 2.08865
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.07798
PRCP prolylcarboxypeptidase (angiotensinase C) 2.06573
VPS26C VPS26 endosomal protein sorting factor C 2.06098
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.05667
STXBP2 syntaxin binding protein 2 2.05632
GALK1 galactokinase 1 2.05231
PDE9A phosphodiesterase 9A 2.05069
SPAG4 sperm associated antigen 4 2.0463
MNMIP1 manchette microtubule inner protein 1 2.04025
DONSON downstream neighbor of SON 2.03052
CORO1A coronin, actin binding protein, 1A 2.03018
BLMH bleomycin hydrolase 2.02424
SLC2A4RG SLC2A4 regulator 2.0242
MXRA8 matrix-remodelling associated 8 2.02191
GOLGA8A golgin A8 family, member A 2.01998
OLFML3 olfactomedin-like 3 2.01544

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.12073
FASTKD5 FAST kinase domains 5 -8.26593
SLC35F2 solute carrier family 35, member F2 -7.87317
CCNB2 cyclin B2 -7.10431
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.80023
ZNF586 zinc finger protein 586 -6.3965
CD320 CD320 molecule -6.19211
ZMIZ1 zinc finger, MIZ-type containing 1 -5.77871
TLR4 toll-like receptor 4 -5.61086
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.71501
MKNK1 MAP kinase interacting serine/threonine kinase 1 -4.50208
LOC124907782 dual specificity protein phosphatase 22 -4.37611
CDC25B cell division cycle 25B -4.35697
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.32779
SPRED2 sprouty-related, EVH1 domain containing 2 -4.27104
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.24428
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.19318
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.17441
VAT1 vesicle amine transport 1 -4.11934
PMM2 phosphomannomutase 2 -4.09351
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.07417
TRIB3 tribbles pseudokinase 3 -3.95411
TM9SF3 transmembrane 9 superfamily member 3 -3.95079
DUSP6 dual specificity phosphatase 6 -3.93642
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.89697
GFOD1 glucose-fructose oxidoreductase domain containing 1 -3.82869
INTS3 integrator complex subunit 3 -3.8279
CCDC86 coiled-coil domain containing 86 -3.81762
NT5DC2 5'-nucleotidase domain containing 2 -3.7931
TCTN1 tectonic family member 1 -3.77915
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.77833
TLCD3A TLC domain containing 3A -3.74429
HYOU1 hypoxia up-regulated 1 -3.72222
TXNL4B thioredoxin-like 4B -3.62908
PPOX protoporphyrinogen oxidase -3.58297
LSR lipolysis stimulated lipoprotein receptor -3.56956
PECR peroxisomal trans-2-enoyl-CoA reductase -3.3855
XPO7 exportin 7 -3.27695
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -3.16302
PDLIM1 PDZ and LIM domain 1 -3.07409
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.05159
COPS7A COP9 signalosome subunit 7A -2.93409
OXA1L oxidase (cytochrome c) assembly 1-like -2.92121
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.85962
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.84337
EAPP E2F-associated phosphoprotein -2.84146
SNX11 sorting nexin 11 -2.70133
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.6693
RALGDS ral guanine nucleotide dissociation stimulator -2.64227
SFTPD surfactant protein D -2.61713
TMEM147 transmembrane protein 147 -2.60149
RAB4A RAB4A, member RAS oncogene family -2.57035
METRN meteorin, glial cell differentiation regulator -2.5551
CAPNS1 calpain, small subunit 1 -2.51606
RIOX1 ribosomal oxygenase 1 -2.50087
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.46668
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.44542
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -2.43169
PRPF4 pre-mRNA processing factor 4 -2.42596
TSPAN6 tetraspanin 6 -2.39818
HMGB3 high mobility group box 3 -2.3862
SERINC5 serine incorporator 5 -2.37247
KIF3A kinesin family member 3A -2.36836
SPRR1B small proline-rich protein 1B -2.36264
SFTPC surfactant protein C -2.3538
IRAK1 interleukin-1 receptor-associated kinase 1 -2.35099
KLF5 Kruppel-like factor 5 (intestinal) -2.34735
WASHC4 WASH complex subunit 4 -2.31224
C2CD5 C2 calcium-dependent domain containing 5 -2.29145
BAG3 BCL2-associated athanogene 3 -2.28866
HMG20B high mobility group 20B -2.28095
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -2.27902
CTTN cortactin -2.26535
GLRX5 glutaredoxin 5 -2.24199
BCAP31 B-cell receptor-associated protein 31 -2.2333
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.22835
HTRA1 HtrA serine peptidase 1 -2.22587
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.22198
PRKCZ protein kinase C, zeta -2.22105
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.21991
HELLS helicase, lymphoid-specific -2.1975
DYNLT3 dynein, light chain, Tctex-type 3 -2.18349
SPRY4 sprouty homolog 4 (Drosophila) -2.17851
PELI1 pellino E3 ubiquitin protein ligase 1 -2.16783
GRN granulin -2.16578
KLK12 kallikrein-related peptidase 12 -2.16406
SMIM10L1 small integral membrane protein 10 like 1 -2.15039
ZNF273 zinc finger protein 273 -2.14959
MNDA myeloid cell nuclear differentiation antigen -2.14804
RBM12B RNA binding motif protein 12B -2.14561
REXO2 RNA exonuclease 2 -2.14416
ANOS1 anosmin 1 -2.14267
CLEC16A C-type lectin domain family 16, member A -2.13357
LOC128966570 alpha-amylase 1B -2.12014
FGF4 fibroblast growth factor 4 -2.10984
KIF18B kinesin family member 18B -2.10051
MEGF9 multiple EGF-like-domains 9 -2.09263
NRIP1 nuclear receptor interacting protein 1 -2.08964
UFM1 ubiquitin-fold modifier 1 -2.08672
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.0801
ZNF263 zinc finger protein 263 -2.07716
E2F8 E2F transcription factor 8 -2.07431
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.07324
CD207 CD207 molecule, langerin -2.07289
KRT6A keratin 6A, type II -2.07001
LYPLA1 lysophospholipase I -2.06067
YJU2 YJU2 splicing factor homolog -2.04526
KRT16 keratin 16, type I -2.04164
FKBP1C FK506 binding protein 1C -2.03965
HAPSTR1 HUWE1 associated protein modifying stress responses -2.03812
PGC progastricsin (pepsinogen C) -2.03801
MARCHF5 membrane associated ring-CH-type finger 5 -2.03163
LAS1L LAS1-like (S. cerevisiae) -2.02723
KXD1 KxDL motif containing 1 -2.0248
ATG14 autophagy related 14 -2.01025