| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 21.18 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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88 genes differentially expressed following the CRCGN010_HEPG2_24H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 6.75065 |
| CTSL | cathepsin L | 5.21522 |
| TXNRD1 | thioredoxin reductase 1 | 3.99062 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.92465 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.90328 |
| SQSTM1 | sequestosome 1 | 3.88924 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.71759 |
| STAP2 | signal transducing adaptor family member 2 | 3.58908 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.48058 |
| RRAGA | Ras-related GTP binding A | 3.44396 |
| MYLK | myosin light chain kinase | 3.32772 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.26946 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.21744 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.17548 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.13639 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.13334 |
| UBQLN2 | ubiquilin 2 | 3.11965 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.08913 |
| SLC75A1 | solute carrier family 75 member 1 | 3.06159 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.99289 |
| CCNF | cyclin F | 2.9676 |
| CCDC92 | coiled-coil domain containing 92 | 2.9459 |
| MVP | major vault protein | 2.84953 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.84708 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.79242 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.75251 |
| CHMP6 | charged multivesicular body protein 6 | 2.73645 |
| VAT1 | vesicle amine transport 1 | 2.55761 |
| MAP7 | microtubule-associated protein 7 | 2.47588 |
| FOSL1 | FOS-like antigen 1 | 2.47562 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.43015 |
| JADE2 | jade family PHD finger 2 | 2.37931 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.33236 |
| LCN2 | lipocalin 2 | 2.2713 |
| MROH7 | maestro heat-like repeat family member 7 | 2.25258 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.22665 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.15024 |
| TUBB6 | tubulin, beta 6 class V | 2.14725 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.13759 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.12099 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 2.11672 |
| CBR1 | carbonyl reductase 1 | 2.10779 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 2.10189 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 2.10147 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.09834 |
| CDC45 | cell division cycle 45 | 2.06181 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 2.04482 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.00289 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -6.99482 |
| LDHD | lactate dehydrogenase D | -6.76958 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -6.75191 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.45887 |
| NRIP1 | nuclear receptor interacting protein 1 | -4.01885 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.9952 |
| TP53BP2 | tumor protein p53 binding protein 2 | -3.82225 |
| HSPB1 | heat shock 27kDa protein 1 | -3.79223 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.68078 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.6386 |
| FAIM | Fas apoptotic inhibitory molecule | -3.59935 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.4399 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.43802 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.37722 |
| CCNB1 | cyclin B1 | -3.33266 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -3.31712 |
| PCNA | proliferating cell nuclear antigen | -2.95936 |
| CHEK1 | checkpoint kinase 1 | -2.9409 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.92105 |
| TLR4 | toll-like receptor 4 | -2.87855 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.86993 |
| YME1L1 | YME1-like 1 ATPase | -2.78138 |
| TRIB3 | tribbles pseudokinase 3 | -2.73852 |
| CDC25B | cell division cycle 25B | -2.70145 |
| RPIA | ribose 5-phosphate isomerase A | -2.69845 |
| MYCBP | MYC binding protein | -2.45669 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.43471 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.36448 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -2.33604 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.32396 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.30603 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.27248 |
| LYPLA1 | lysophospholipase I | -2.26558 |
| USP6NL | USP6 N-terminal like | -2.25158 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.11318 |
| MOAP1 | modulator of apoptosis 1 | -2.09068 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.0809 |
| PIGF | phosphatidylinositol glycan anchor biosynthesis, class F | -2.07565 |
| EDN1 | endothelin 1 | -2.07562 |
| KIF14 | kinesin family member 14 | -2.0603 |
