CRCGN010_HEPG2_24H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 10.59 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN010_HEPG2_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MNAT1 MNAT CDK-activating kinase assembly factor 1 6.82515
CXCL2 chemokine (C-X-C motif) ligand 2 6.28224
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.61001
C2CD2 C2 calcium-dependent domain containing 2 3.91804
GPER1 G protein-coupled estrogen receptor 1 3.74815
CEMIP2 cell migration inducing hyaluronidase 2 3.5735
RPP38 ribonuclease P/MRP 38kDa subunit 3.54067
ANO1 anoctamin 1, calcium activated chloride channel 3.53365
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.41726
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.3937
CCNF cyclin F 3.38353
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.29252
PRKCH protein kinase C, eta 3.26376
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.19686
LCN2 lipocalin 2 3.18635
ADAM10 ADAM metallopeptidase domain 10 3.10675
HLA-DMA major histocompatibility complex, class II, DM alpha 3.05174
CCL2 chemokine (C-C motif) ligand 2 2.85707
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.74356
SLC38A6 solute carrier family 38, member 6 2.72572
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.71436
PLS1 plastin 1 2.61648
BPHL biphenyl hydrolase-like (serine hydrolase) 2.5681
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.50357
SCRN1 secernin 1 2.41942
GSTZ1 glutathione S-transferase zeta 1 2.38916
KLHL9 kelch-like family member 9 2.38432
SIX1 SIX homeobox 1 2.34766
STK10 serine/threonine kinase 10 2.30234
CFAP298 cilia and flagella associated protein 298 2.29662
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.17386
TIAM1 T-cell lymphoma invasion and metastasis 1 2.17149
SLC75A1 solute carrier family 75 member 1 2.13068
NPDC1 neural proliferation, differentiation and control, 1 2.13056
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.0543
NOSIP nitric oxide synthase interacting protein 2.05374
CYCS cytochrome c, somatic 2.04539

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -6.85019
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.9684
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.99632
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.83601
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.76455
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.75684
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.57556
NUP85 nucleoporin 85kDa -3.5345
CCNB2 cyclin B2 -3.39948
ZDHHC6 zinc finger, DHHC-type containing 6 -3.33712
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.2136
TOR1A torsin family 1, member A (torsin A) -3.10372
WDR7 WD repeat domain 7 -3.08463
GOLT1B golgi transport 1B -3.07993
TUBB6 tubulin, beta 6 class V -3.07944
MRPS2 mitochondrial ribosomal protein S2 -3.01531
PRPF4 pre-mRNA processing factor 4 -3.01018
MAP2K5 mitogen-activated protein kinase kinase 5 -2.77338
FKBP4 FK506 binding protein 4, 59kDa -2.70783
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.69983
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.66164
FASTKD5 FAST kinase domains 5 -2.64778
FGFR4 fibroblast growth factor receptor 4 -2.60517
MRPL46 mitochondrial ribosomal protein L46 -2.529
TMEM94 transmembrane protein 94 -2.5032
MRPL58 mitochondrial ribosomal protein L58 -2.48821
KLHDC2 kelch domain containing 2 -2.48491
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.39728
NGRN neugrin, neurite outgrowth associated -2.35588
OXA1L oxidase (cytochrome c) assembly 1-like -2.30665
RAI14 retinoic acid induced 14 -2.26531
SNCB synuclein, beta -2.23303
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.20687
CALY calcyon neuron-specific vesicular protein -2.2039
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.19519
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.17158
GNAS GNAS complex locus -2.14404
MRPS7 mitochondrial ribosomal protein S7 -2.13409
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.13155
ADPGK ADP-dependent glucokinase -2.12981
PEG10 paternally expressed 10 -2.11978
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.09409
ZNF274 zinc finger protein 274 -2.08384
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.08253
DCK deoxycytidine kinase -2.07686
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.07148
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.0132