CRCGN010_HEPG2_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 5.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN010_HEPG2_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.6988
MAP7 microtubule-associated protein 7 5.60952
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 5.15508
RPL39L ribosomal protein L39-like 4.41482
MYLK myosin light chain kinase 4.09433
STAP2 signal transducing adaptor family member 2 3.97059
MOK MOK protein kinase 3.9538
STK10 serine/threonine kinase 10 3.77904
CIAO3 cytosolic iron-sulfur assembly component 3 3.54514
COPS7A COP9 signalosome subunit 7A 3.32456
EAPP E2F-associated phosphoprotein 3.27674
HLA-DMA major histocompatibility complex, class II, DM alpha 3.25389
JADE2 jade family PHD finger 2 3.09963
CARMIL1 capping protein regulator and myosin 1 linker 1 2.99718
GSTZ1 glutathione S-transferase zeta 1 2.86896
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.84618
E2F2 E2F transcription factor 2 2.81921
RPP38 ribonuclease P/MRP 38kDa subunit 2.77326
CDC45 cell division cycle 45 2.717
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.60627
BPHL biphenyl hydrolase-like (serine hydrolase) 2.59542
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.5783
CHMP6 charged multivesicular body protein 6 2.56476
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.48692
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.46728
LPAR2 lysophosphatidic acid receptor 2 2.42164
ADRB2 adrenoceptor beta 2, surface 2.37378
BACE2 beta-site APP-cleaving enzyme 2 2.35514
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.32743
HDGFL3 HDGF like 3 2.30146
ANO1 anoctamin 1, calcium activated chloride channel 2.27589
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26823
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.25811
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.20514
CHN1 chimerin 1 2.17207
CDCA3 cell division cycle associated 3 2.15779
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.1442
ZNF589 zinc finger protein 589 2.11412
CCNA1 cyclin A1 2.0881
DIPK1A divergent protein kinase domain 1A 2.04896
NANOS3 nanos homolog 3 (Drosophila) 2.01734

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.68811
NT5DC2 5'-nucleotidase domain containing 2 -4.22996
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.16085
TLR4 toll-like receptor 4 -4.03123
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.84594
RAI14 retinoic acid induced 14 -3.60457
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.54738
PCNA proliferating cell nuclear antigen -3.49798
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.2457
ISOC1 isochorismatase domain containing 1 -3.09307
PRPF4 pre-mRNA processing factor 4 -2.9641
FASTKD5 FAST kinase domains 5 -2.95612
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.9444
LDHD lactate dehydrogenase D -2.78811
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.78163
PEG10 paternally expressed 10 -2.77633
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.75083
NRIP1 nuclear receptor interacting protein 1 -2.48524
DNM1L dynamin 1-like -2.38238
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.3583
USP6NL USP6 N-terminal like -2.32406
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.29478
DSG2 desmoglein 2 -2.00424