| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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62 genes differentially expressed following the CRCGN010_HEPG2_24H:E18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SQOR | sulfide quinone oxidoreductase | 5.64234 |
| STIMATE | STIM activating enhancer | 4.80386 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 4.76599 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.53666 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 4.45952 |
| UBQLN2 | ubiquilin 2 | 4.31702 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 4.17758 |
| NOTCH1 | notch 1 | 4.16939 |
| EPHB2 | EPH receptor B2 | 4.15527 |
| ADRB2 | adrenoceptor beta 2, surface | 3.57933 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.53344 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.47163 |
| ABHD6 | abhydrolase domain containing 6 | 3.14561 |
| CYCS | cytochrome c, somatic | 3.11817 |
| MEST | mesoderm specific transcript | 3.02113 |
| TBC1D10C | TBC1 domain family, member 10C | 2.98603 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.70023 |
| CSK | c-src tyrosine kinase | 2.6885 |
| HAT1 | histone acetyltransferase 1 | 2.67814 |
| PLSCR3 | phospholipid scramblase 3 | 2.56773 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.40918 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.36962 |
| MCM3 | minichromosome maintenance complex component 3 | 2.27985 |
| PRR15L | proline rich 15-like | 2.25083 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.22516 |
| E2F2 | E2F transcription factor 2 | 2.17712 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.14817 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.14297 |
| ECD | ecdysoneless homolog (Drosophila) | 2.12614 |
| EFNA4 | ephrin-A4 | 2.10765 |
| CILK1 | ciliogenesis associated kinase 1 | 2.04771 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 2.04185 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.03938 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 2.03879 |
| CBY1 | chibby homolog 1 (Drosophila) | 2.0384 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TLCD3A | TLC domain containing 3A | -5.9244 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.71987 |
| GNAS | GNAS complex locus | -5.54448 |
| DUSP6 | dual specificity phosphatase 6 | -4.27298 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.1788 |
| TRIB3 | tribbles pseudokinase 3 | -4.02871 |
| RPIA | ribose 5-phosphate isomerase A | -3.92457 |
| WASHC4 | WASH complex subunit 4 | -3.59248 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.37601 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.36696 |
| GDF15 | growth differentiation factor 15 | -3.26049 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.25286 |
| CHMP4B | charged multivesicular body protein 4B | -3.20886 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.06698 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.98683 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.95994 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.80621 |
| NGRN | neugrin, neurite outgrowth associated | -2.60033 |
| ZNF586 | zinc finger protein 586 | -2.53099 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.4234 |
| COG2 | component of oligomeric golgi complex 2 | -2.39433 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -2.23149 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -2.19781 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -2.12685 |
| TGFB3 | transforming growth factor, beta 3 | -2.09676 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.06294 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.00847 |
