CRCGN010_HEPG2_24H:E19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopiperidine 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN010_HEPG2_24H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 8.47778
UBQLN2 ubiquilin 2 8.40316
LCN2 lipocalin 2 5.89537
CBR3 carbonyl reductase 3 4.81694
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.57576
CXCL2 chemokine (C-X-C motif) ligand 2 4.57255
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.42448
CHMP6 charged multivesicular body protein 6 4.24653
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.99483
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.88242
ALDOC aldolase C, fructose-bisphosphate 3.67671
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.60951
ZFP36 ZFP36 ring finger protein 3.58902
ZNF589 zinc finger protein 589 3.49898
NOSIP nitric oxide synthase interacting protein 3.10697
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.93611
GPATCH8 G patch domain containing 8 2.7285
TIAM1 T-cell lymphoma invasion and metastasis 1 2.61449
DMTF1 cyclin D binding myb-like transcription factor 1 2.53744
LOC122526780 uncharacterized LOC122526780 2.45281
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.40599
HLA-DMA major histocompatibility complex, class II, DM alpha 2.35538
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.31909
MYLK myosin light chain kinase 2.25677
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.20147
ANO1 anoctamin 1, calcium activated chloride channel 2.17927
CHN1 chimerin 1 2.03676
IFI44 interferon-induced protein 44 2.00684

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.97502
GTPBP8 GTP-binding protein 8 (putative) -4.82242
ADI1 acireductone dioxygenase 1 -4.51628
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.39539
MRPS2 mitochondrial ribosomal protein S2 -4.39345
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.93964
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.75982
DNM1L dynamin 1-like -3.67435
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.65637
DERA deoxyribose-phosphate aldolase (putative) -3.42376
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.38819
RAI14 retinoic acid induced 14 -3.33695
TOR1A torsin family 1, member A (torsin A) -2.9619
EIF5 eukaryotic translation initiation factor 5 -2.85077
MTFR1 mitochondrial fission regulator 1 -2.79742
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.53666
FOS FBJ murine osteosarcoma viral oncogene homolog -2.34083
GDF15 growth differentiation factor 15 -2.33738
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.33333
NGRN neugrin, neurite outgrowth associated -2.23943
TM9SF3 transmembrane 9 superfamily member 3 -2.17989
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.09237
PDZD2 PDZ domain containing 2 -2.03983