CRCGN010_HEPG2_24H:E23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopiperidine 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN010_HEPG2_24H:E23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 5.71578
GPER1 G protein-coupled estrogen receptor 1 5.29186
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.86774
NMU neuromedin U 4.77252
AMDHD2 amidohydrolase domain containing 2 4.75193
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.66195
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.41168
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.3826
CYCS cytochrome c, somatic 4.29885
NOTCH1 notch 1 4.17811
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.72552
DIPK1A divergent protein kinase domain 1A 3.72117
UFM1 ubiquitin-fold modifier 1 3.15078
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.08484
GSTZ1 glutathione S-transferase zeta 1 2.9077
GATA3 GATA binding protein 3 2.86964
MEST mesoderm specific transcript 2.73894
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.72715
RBKS ribokinase 2.66221
GLI3 GLI family zinc finger 3 2.53713
RPL36A ribosomal protein L36a 2.38842
OSR2 odd-skipped related transciption factor 2 2.35527
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.3484
COL5A1 collagen, type V, alpha 1 2.33793
ESD esterase D 2.29075
TNIP1 TNFAIP3 interacting protein 1 2.2579
TKFC triokinase/FMN cyclase 2.249
TDO2 tryptophan 2,3-dioxygenase 2.22832
ADIPOR2 adiponectin receptor 2 2.20057
ZNF589 zinc finger protein 589 2.19819
GPATCH8 G patch domain containing 8 2.1339
PRR15L proline rich 15-like 2.11157
CSRNP2 cysteine-serine-rich nuclear protein 2 2.10401
GIGYF2 GRB10 interacting GYF protein 2 2.09762
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 2.09175
KMT5B lysine methyltransferase 5B 2.07226
GABARAP GABA(A) receptor-associated protein 2.06653
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.0394
BBS1 Bardet-Biedl syndrome 1 2.03619
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.02985
EXOC5 exocyst complex component 5 2.01823
NOSIP nitric oxide synthase interacting protein 2.00906

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.31846
CD320 CD320 molecule -5.08636
MRPS2 mitochondrial ribosomal protein S2 -4.95417
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.89992
ADI1 acireductone dioxygenase 1 -4.82712
RPN1 ribophorin I -4.64535
TLCD3A TLC domain containing 3A -4.52373
TM9SF3 transmembrane 9 superfamily member 3 -4.50954
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.49462
FAIM Fas apoptotic inhibitory molecule -4.47002
KDM3A lysine (K)-specific demethylase 3A -4.40861
ENOPH1 enolase-phosphatase 1 -4.24807
TMEM109 transmembrane protein 109 -4.19711
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.90803
PPOX protoporphyrinogen oxidase -3.06595
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.01448
CRELD2 cysteine-rich with EGF-like domains 2 -2.69513
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.66009
C1QL1 complement component 1, q subcomponent-like 1 -2.62035
RFC2 replication factor C (activator 1) 2, 40kDa -2.60564
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.59254
YEATS4 YEATS domain containing 4 -2.4248
CCNB1 cyclin B1 -2.35357
RAI1 retinoic acid induced 1 -2.19911
MON1B MON1 secretory trafficking family member B -2.16592
SMIM29 small integral membrane protein 29 -2.04705
HYOU1 hypoxia up-regulated 1 -2.02412