CRCGN010_HEPG2_24H:F01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitrosoazocane 21.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN010_HEPG2_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 4.30324
PMM2 phosphomannomutase 2 4.30126
PRR15L proline rich 15-like 4.15031
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.08316
UBQLN2 ubiquilin 2 3.87889
CSK c-src tyrosine kinase 3.76441
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.61176
NOSIP nitric oxide synthase interacting protein 3.51689
NOTCH1 notch 1 3.32939
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.1941
MEST mesoderm specific transcript 3.19215
CIAO3 cytosolic iron-sulfur assembly component 3 3.01663
CHMP6 charged multivesicular body protein 6 2.91647
HSPA8 heat shock 70kDa protein 8 2.58901
SLC75A1 solute carrier family 75 member 1 2.50825
ZFP36 ZFP36 ring finger protein 2.33531
USP6NL USP6 N-terminal like 2.24744
CCNA1 cyclin A1 2.16497
LCN2 lipocalin 2 2.07704
H2BC21 H2B clustered histone 21 2.02784

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.7359
ZNF586 zinc finger protein 586 -5.54925
FBXL12 F-box and leucine-rich repeat protein 12 -4.41344
LDHD lactate dehydrogenase D -4.16131
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.66761
SLC35F2 solute carrier family 35, member F2 -3.40317
BLCAP bladder cancer associated protein -3.13738
CD320 CD320 molecule -2.92841
FBXO7 F-box protein 7 -2.55771
MAPK13 mitogen-activated protein kinase 13 -2.48725
SCCPDH saccharopine dehydrogenase (putative) -2.4371
OXA1L oxidase (cytochrome c) assembly 1-like -2.39932
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.01986