CRCGN010_HEPG2_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitrosoazocane 10.55 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN010_HEPG2_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 6.95313
CHMP6 charged multivesicular body protein 6 6.35448
E2F2 E2F transcription factor 2 4.99442
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.96933
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9204
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.8805
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.63216
GPATCH8 G patch domain containing 8 4.23272
NMU neuromedin U 4.01622
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.67178
PRR15L proline rich 15-like 3.66502
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.54022
PEX11A peroxisomal biogenesis factor 11 alpha 3.52037
GSTZ1 glutathione S-transferase zeta 1 3.38832
SOCS2 suppressor of cytokine signaling 2 3.14826
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.97528
EDN1 endothelin 1 2.93888
CYB561 cytochrome b561 2.91328
LOC122526780 uncharacterized LOC122526780 2.70777
MAP7 microtubule-associated protein 7 2.59232
ZNF318 zinc finger protein 318 2.54268
GPER1 G protein-coupled estrogen receptor 1 2.46955
SORBS3 sorbin and SH3 domain containing 3 2.46384
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.44146
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.43272
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.39377
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.34638
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.31583
HLA-DMA major histocompatibility complex, class II, DM alpha 2.2722
EPB41L2 erythrocyte membrane protein band 4.1-like 2 2.27043
PFKL phosphofructokinase, liver 2.26853
PRPF18 pre-mRNA processing factor 18 2.23829
PMM2 phosphomannomutase 2 2.13342
TIAM1 T-cell lymphoma invasion and metastasis 1 2.12991
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.093
GTF2IRD1 GTF2I repeat domain containing 1 2.06906
LOC102724560 cystathionine beta-synthase 2.06481
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.0564
JADE2 jade family PHD finger 2 2.05115
C1RL complement component 1, r subcomponent-like 2.02718
DUSP3 dual specificity phosphatase 3 2.01941
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.00906

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.30973
ANKRD10 ankyrin repeat domain 10 -5.23219
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.18188
KDM3A lysine (K)-specific demethylase 3A -5.14739
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.11531
DSG2 desmoglein 2 -5.08597
MRPS2 mitochondrial ribosomal protein S2 -4.74797
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.74374
CCDC86 coiled-coil domain containing 86 -4.63981
CCNB1 cyclin B1 -4.01984
LOC124907782 dual specificity protein phosphatase 22 -3.93508
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.76652
CHMP4B charged multivesicular body protein 4B -3.61605
SNX11 sorting nexin 11 -3.61396
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.0482
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.80368
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.6836
EIF5 eukaryotic translation initiation factor 5 -2.67514
ITGB1BP1 integrin beta 1 binding protein 1 -2.53739
CCNB2 cyclin B2 -2.44698
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.33721
METTL1 methyltransferase like 1 -2.15382
FOS FBJ murine osteosarcoma viral oncogene homolog -2.15339
DDIT4 DNA-damage-inducible transcript 4 -2.10973
ZBTB11 zinc finger and BTB domain containing 11 -2.05537