CRCGN010_HEPG2_24H:F03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitrosoazocane 5.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN010_HEPG2_24H:F03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 8.75721
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.03175
ATP11B ATPase, class VI, type 11B 4.80049
MAP7 microtubule-associated protein 7 4.35997
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.34346
PRR15L proline rich 15-like 4.0967
PRKCH protein kinase C, eta 4.05184
CARMIL1 capping protein regulator and myosin 1 linker 1 3.77527
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.67662
STK10 serine/threonine kinase 10 3.4055
CBR3 carbonyl reductase 3 3.15063
LPAR2 lysophosphatidic acid receptor 2 3.0396
SORBS3 sorbin and SH3 domain containing 3 2.98714
GPER1 G protein-coupled estrogen receptor 1 2.96245
TIAM1 T-cell lymphoma invasion and metastasis 1 2.85048
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.82212
PARP1 poly (ADP-ribose) polymerase 1 2.82095
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.70162
TEX10 testis expressed 10 2.48032
CASC3 cancer susceptibility candidate 3 2.44287
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.4344
CXCL2 chemokine (C-X-C motif) ligand 2 2.43402
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.38726
KDM5A lysine (K)-specific demethylase 5A 2.36145
EVL Enah/Vasp-like 2.31902
SNAP25 synaptosomal-associated protein, 25kDa 2.20014
JADE2 jade family PHD finger 2 2.1956
SFTPB surfactant protein B 2.18044
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.15962
CHN1 chimerin 1 2.1424
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.13856
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.13122
NPDC1 neural proliferation, differentiation and control, 1 2.11859
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.10735
TLK2 tousled-like kinase 2 2.10374
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.06421
TBP TATA box binding protein 2.0523
HLA-DRA major histocompatibility complex, class II, DR alpha 2.04847
CCL2 chemokine (C-C motif) ligand 2 2.02398
SAMD9 sterile alpha motif domain containing 9 2.02015

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -6.67762
CCNB1 cyclin B1 -6.57602
C2CD5 C2 calcium-dependent domain containing 5 -6.28158
ZNF586 zinc finger protein 586 -6.2025
DHRS7 dehydrogenase/reductase (SDR family) member 7 -6.05985
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.47322
GTPBP8 GTP-binding protein 8 (putative) -5.3054
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.70965
YME1L1 YME1-like 1 ATPase -4.59805
PCNA proliferating cell nuclear antigen -3.79838
FGFR4 fibroblast growth factor receptor 4 -3.70771
SCAND1 SCAN domain containing 1 -3.20679
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.0633
STMN1 stathmin 1 -2.91103
HAT1 histone acetyltransferase 1 -2.68983
ZNF274 zinc finger protein 274 -2.61892
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.56732
FASTKD5 FAST kinase domains 5 -2.41514
GNAS GNAS complex locus -2.34379
KEAP1 kelch-like ECH-associated protein 1 -2.16564
CRYZ crystallin, zeta (quinone reductase) -2.13167
PLA2G15 phospholipase A2, group XV -2.10535
OXA1L oxidase (cytochrome c) assembly 1-like -2.0559
FOS FBJ murine osteosarcoma viral oncogene homolog -2.04059
DERA deoxyribose-phosphate aldolase (putative) -2.02938