CRCGN010_HEPG2_24H:F07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN010_HEPG2_24H:F07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.43409
MYLK myosin light chain kinase 6.99654
CHN1 chimerin 1 6.12607
DYNLT3 dynein, light chain, Tctex-type 3 3.81085
EPN2 epsin 2 3.34719
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.21498
CEMIP2 cell migration inducing hyaluronidase 2 3.08288
PPARG peroxisome proliferator-activated receptor gamma 2.95902
CHMP6 charged multivesicular body protein 6 2.91989
PNKP polynucleotide kinase 3'-phosphatase 2.8719
SYNE2 spectrin repeat containing, nuclear envelope 2 2.81369
UFM1 ubiquitin-fold modifier 1 2.74153
SNAP25 synaptosomal-associated protein, 25kDa 2.69657
BPHL biphenyl hydrolase-like (serine hydrolase) 2.66968
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.57219
SQOR sulfide quinone oxidoreductase 2.48289
GATA3 GATA binding protein 3 2.30739
PRR15L proline rich 15-like 2.28284
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.21177
DENND2D DENN/MADD domain containing 2D 2.20734
MAP7 microtubule-associated protein 7 2.19377
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.19084
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.09581
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.08597
WIPF2 WAS/WASL interacting protein family, member 2 2.04742
CBR3 carbonyl reductase 3 2.00282

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.59124
TM9SF3 transmembrane 9 superfamily member 3 -5.12778
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.86697
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.56878
NRIP1 nuclear receptor interacting protein 1 -4.41697
DNM1L dynamin 1-like -4.18029
PRPF4 pre-mRNA processing factor 4 -3.1792
CDC20 cell division cycle 20 -3.13104
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.02368
KDM3A lysine (K)-specific demethylase 3A -2.97018
ZNF586 zinc finger protein 586 -2.95716
FHL2 four and a half LIM domains 2 -2.91877
MRPS16 mitochondrial ribosomal protein S16 -2.80578
TWF2 twinfilin actin binding protein 2 -2.69368
MRPS2 mitochondrial ribosomal protein S2 -2.55875
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.5558
CCNB2 cyclin B2 -2.54748
TLCD3A TLC domain containing 3A -2.48908
PLK1 polo-like kinase 1 -2.44912
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.34775
LDHD lactate dehydrogenase D -2.28259
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.22463
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.20299
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.12447
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.11063