CRCGN010_HEPG2_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN010_HEPG2_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.14564
CSK c-src tyrosine kinase 4.35453
PRR15L proline rich 15-like 4.30487
MYLK myosin light chain kinase 4.06035
PPARG peroxisome proliferator-activated receptor gamma 4.02251
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.9667
SNAP25 synaptosomal-associated protein, 25kDa 3.82761
MAP7 microtubule-associated protein 7 3.50928
CYCS cytochrome c, somatic 3.50191
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.14713
NMU neuromedin U 3.12342
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.9132
FZD7 frizzled class receptor 7 2.91241
TESK1 testis-specific kinase 1 2.90948
TREM1 triggering receptor expressed on myeloid cells 1 2.83003
UBQLN2 ubiquilin 2 2.81792
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.80329
PNKP polynucleotide kinase 3'-phosphatase 2.77182
MAMLD1 mastermind-like domain containing 1 2.75655
E2F2 E2F transcription factor 2 2.69074
NOSIP nitric oxide synthase interacting protein 2.50621
BPHL biphenyl hydrolase-like (serine hydrolase) 2.17536
EPN2 epsin 2 2.16489

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.35058
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.41095
SLC35F2 solute carrier family 35, member F2 -4.74801
ADI1 acireductone dioxygenase 1 -4.71597
CD320 CD320 molecule -4.03019
CCNB2 cyclin B2 -3.95597
LDHD lactate dehydrogenase D -3.92481
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.92133
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.60867
OXA1L oxidase (cytochrome c) assembly 1-like -3.43747
PCNA proliferating cell nuclear antigen -3.26495
RNF167 ring finger protein 167 -3.18264
FBXL12 F-box and leucine-rich repeat protein 12 -3.14441
MAPK13 mitogen-activated protein kinase 13 -3.11043
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.01453
HEATR1 HEAT repeat containing 1 -2.97616
VAT1 vesicle amine transport 1 -2.95734
LAP3 leucine aminopeptidase 3 -2.91591
C2CD5 C2 calcium-dependent domain containing 5 -2.88326
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.77543
TRIB3 tribbles pseudokinase 3 -2.51958
DNASE1L2 deoxyribonuclease I-like 2 -2.30593
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.27376
MACF1 microtubule-actin crosslinking factor 1 -2.23169
MTA1 metastasis associated 1 -2.01163