CRCGN010_HEPG2_24H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN010_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 8.72984
CHMP6 charged multivesicular body protein 6 8.66126
CHN1 chimerin 1 4.92317
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.21606
UBQLN2 ubiquilin 2 4.06151
TREM1 triggering receptor expressed on myeloid cells 1 4.00453
SMIM40 small integral membrane protein 40 3.98885
CYCS cytochrome c, somatic 3.80718
GRWD1 glutamate-rich WD repeat containing 1 3.80344
MAP7 microtubule-associated protein 7 3.71707
HLA-DMA major histocompatibility complex, class II, DM alpha 3.23732
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.07488
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.93782
SKIC8 SKI8 subunit of superkiller complex 2.39076
STXBP2 syntaxin binding protein 2 2.37569
SFTPB surfactant protein B 2.1036
DIPK1A divergent protein kinase domain 1A 2.09975
RAB4A RAB4A, member RAS oncogene family 2.03892

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -6.03597
CD320 CD320 molecule -5.64258
C2CD5 C2 calcium-dependent domain containing 5 -4.48541
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.4639
MRPS16 mitochondrial ribosomal protein S16 -4.29906
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.27845
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.27811
PRCP prolylcarboxypeptidase (angiotensinase C) -4.22894
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.18779
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.01823
CCNB2 cyclin B2 -3.88715
PCNA proliferating cell nuclear antigen -3.61061
TOR1A torsin family 1, member A (torsin A) -2.64021
MACF1 microtubule-actin crosslinking factor 1 -2.49012
ETNK1 ethanolamine kinase 1 -2.41165
MPC2 mitochondrial pyruvate carrier 2 -2.27647
RNF167 ring finger protein 167 -2.14012
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.05972
REEP5 receptor accessory protein 5 -2.02914
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.01594
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.00883