CRCGN010_HEPG2_24H:F16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethylformamide 5.33 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN010_HEPG2_24H:F16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCH protein kinase C, eta 6.70998
STIMATE STIM activating enhancer 5.28173
STAP2 signal transducing adaptor family member 2 5.12278
E2F2 E2F transcription factor 2 5.01043
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.88135
UBQLN2 ubiquilin 2 4.66015
SNAP25 synaptosomal-associated protein, 25kDa 4.33506
TREM1 triggering receptor expressed on myeloid cells 1 4.25104
PFKL phosphofructokinase, liver 3.84318
TIAM1 T-cell lymphoma invasion and metastasis 1 3.52459
HEBP1 heme binding protein 1 3.07527
GSTZ1 glutathione S-transferase zeta 1 3.04639
H2BC12 H2B clustered histone 12 3.03164
ANO10 anoctamin 10 2.93265
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.81974
KDM5A lysine (K)-specific demethylase 5A 2.73179
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.72313
SNX7 sorting nexin 7 2.67221
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.57225
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.53021
CYB561 cytochrome b561 2.51594
PADI2 peptidyl arginine deiminase, type II 2.44027
LPAR2 lysophosphatidic acid receptor 2 2.42551
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.37342
TSPAN31 tetraspanin 31 2.3692
NUP133 nucleoporin 133kDa 2.35471
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.34345
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.3232
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26483
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.21829
DYNLT3 dynein, light chain, Tctex-type 3 2.19634
IL1RAP interleukin 1 receptor accessory protein 2.19419
CHN1 chimerin 1 2.19119
GPATCH8 G patch domain containing 8 2.18505
ACTL7A actin-like 7A 2.17533
METTL1 methyltransferase like 1 2.16812
PCDH12 protocadherin 12 2.16592
TSPAN7 tetraspanin 7 2.1526
DIPK1A divergent protein kinase domain 1A 2.14447
PGLYRP4 peptidoglycan recognition protein 4 2.11336
VCAM1 vascular cell adhesion molecule 1 2.10384
PRDM1 PR domain containing 1, with ZNF domain 2.0948
CCNF cyclin F 2.08418
EPHA3 EPH receptor A3 2.07452
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.04853
KLHL9 kelch-like family member 9 2.03971
KRT38 keratin 38, type I 2.02077

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.59725
OXA1L oxidase (cytochrome c) assembly 1-like -6.03724
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.64153
LDHD lactate dehydrogenase D -5.2471
PCCB propionyl CoA carboxylase, beta polypeptide -4.68489
ZNF586 zinc finger protein 586 -4.64864
WASHC4 WASH complex subunit 4 -4.56676
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.3123
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.3008
PLK1 polo-like kinase 1 -4.19561
CCNB2 cyclin B2 -3.91428
PEG10 paternally expressed 10 -3.82518
TXNRD1 thioredoxin reductase 1 -3.63395
TLCD3A TLC domain containing 3A -3.22946
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.17591
CPNE3 copine III -3.04803
CD320 CD320 molecule -2.93594
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.9355
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.76227
RNF167 ring finger protein 167 -2.69165
NRIP1 nuclear receptor interacting protein 1 -2.55408
ATXN2 ataxin 2 -2.49079
ATAD2B ATPase family, AAA domain containing 2B -2.35812
ITGB1BP1 integrin beta 1 binding protein 1 -2.29719
OSBPL8 oxysterol binding protein-like 8 -2.15081
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -2.12083
BCAR3 breast cancer anti-estrogen resistance 3 -2.07331
CCNH cyclin H -2.06171
ADI1 acireductone dioxygenase 1 -2.05383
OSBPL11 oxysterol binding protein-like 11 -2.04265
SYNJ2BP synaptojanin 2 binding protein -2.02585
RBM15B RNA binding motif protein 15B -2.01996
SYNRG synergin, gamma -2.0105