CRCGN010_HEPG2_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furfural 9.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN010_HEPG2_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.94045
MAP7 microtubule-associated protein 7 7.65442
KCNK1 potassium channel, two pore domain subfamily K, member 1 6.64307
CBR3 carbonyl reductase 3 5.85765
GPER1 G protein-coupled estrogen receptor 1 5.6382
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.17115
E2F2 E2F transcription factor 2 4.9421
AMDHD2 amidohydrolase domain containing 2 4.8368
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.7103
NMU neuromedin U 4.66275
RPP38 ribonuclease P/MRP 38kDa subunit 4.55035
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.3238
LYN LYN proto-oncogene, Src family tyrosine kinase 4.13058
GLOD4 glyoxalase domain containing 4 3.562
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.45208
ABHD6 abhydrolase domain containing 6 3.06457
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.0107
PRR15L proline rich 15-like 2.9574
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.86888
RAB21 RAB21, member RAS oncogene family 2.8488
CHN1 chimerin 1 2.8007
SSBP2 single-stranded DNA binding protein 2 2.77822
RBKS ribokinase 2.6999
GPATCH8 G patch domain containing 8 2.66057
LOC122526780 uncharacterized LOC122526780 2.64795
SMNDC1 survival motor neuron domain containing 1 2.6479
KEAP1 kelch-like ECH-associated protein 1 2.58355
CCNF cyclin F 2.54225
EVL Enah/Vasp-like 2.54055
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.5386
MED23 mediator complex subunit 23 2.53735
PARP2 poly (ADP-ribose) polymerase 2 2.5343
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.47035
TESK1 testis-specific kinase 1 2.4034
FN3KRP fructosamine 3 kinase related protein 2.27335
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.27183
EGF epidermal growth factor 2.234
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.2214
RYR3 ryanodine receptor 3 2.1685
PRB3 proline-rich protein BstNI subfamily 3 2.1499
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.12681
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.0965
HOOK1 hook microtubule-tethering protein 1 2.0845
EPHA3 EPH receptor A3 2.06513
GFI1B growth factor independent 1B transcription repressor 2.06255
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.0447
PLSCR3 phospholipid scramblase 3 2.033
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.02115

decreased expression

Symbol Name Standardized Value
DSG2 desmoglein 2 -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.3681
TUBB6 tubulin, beta 6 class V -5.31205
TRIB3 tribbles pseudokinase 3 -5.2488
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.963
RPIA ribose 5-phosphate isomerase A -4.89545
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.6196
UBE3C ubiquitin protein ligase E3C -4.41575
UGDH UDP-glucose 6-dehydrogenase -3.66115
ZNF586 zinc finger protein 586 -3.6011
FGFR4 fibroblast growth factor receptor 4 -3.52225
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.4355
GNAS GNAS complex locus -3.4258
NGRN neugrin, neurite outgrowth associated -3.3351
PECR peroxisomal trans-2-enoyl-CoA reductase -3.22015
TLCD3A TLC domain containing 3A -3.1246
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.0399
BLCAP bladder cancer associated protein -2.9911
CCNB1 cyclin B1 -2.9203
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.9066
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.75942
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.74775
TLR4 toll-like receptor 4 -2.68445
S100A10 S100 calcium binding protein A10 -2.6816
HMG20B high mobility group 20B -2.51522
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.32947
ZNF45 zinc finger protein 45 -2.17873
ZNF222 zinc finger protein 222 -2.0247
RNFT1-DT RNFT1 divergent transcript -2.0161