CRCGN010_HEPG2_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furfural 1.21 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN010_HEPG2_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.66611
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.32135
CYCS cytochrome c, somatic 5.26657
GPER1 G protein-coupled estrogen receptor 1 4.75526
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.51816
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.40832
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.28485
TEX10 testis expressed 10 4.00212
CARMIL1 capping protein regulator and myosin 1 linker 1 3.88632
DYNLT3 dynein, light chain, Tctex-type 3 3.686
BZW2 basic leucine zipper and W2 domains 2 3.62953
CSK c-src tyrosine kinase 3.6093
UBQLN2 ubiquilin 2 3.58132
CHMP6 charged multivesicular body protein 6 3.52937
CRTAP cartilage associated protein 3.50213
LCN2 lipocalin 2 3.48109
FZD7 frizzled class receptor 7 3.44668
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.3613
RPP38 ribonuclease P/MRP 38kDa subunit 3.12561
DIPK1A divergent protein kinase domain 1A 3.02117
MAP7 microtubule-associated protein 7 2.80023
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.61024
FRS2 fibroblast growth factor receptor substrate 2 2.54205
MAMLD1 mastermind-like domain containing 1 2.50189
EGF epidermal growth factor 2.33936
SKIC2 SKI2 subunit of superkiller complex 2.33585
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.28643
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.27479
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.26988
TIAM1 T-cell lymphoma invasion and metastasis 1 2.1805
NPDC1 neural proliferation, differentiation and control, 1 2.03889
CNPY3 canopy FGF signaling regulator 3 2.0049

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.44112
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -5.20174
SLC35F2 solute carrier family 35, member F2 -4.42729
TLR4 toll-like receptor 4 -4.25426
TUBB6 tubulin, beta 6 class V -4.19239
TRIB3 tribbles pseudokinase 3 -3.77327
ZNF586 zinc finger protein 586 -3.60392
CDC20 cell division cycle 20 -3.57605
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.31584
CCNB2 cyclin B2 -3.1339
MAPK13 mitogen-activated protein kinase 13 -3.1145
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.76307
RNF167 ring finger protein 167 -2.73936
FGFR4 fibroblast growth factor receptor 4 -2.65649
GNAS GNAS complex locus -2.54463
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.31277
OXA1L oxidase (cytochrome c) assembly 1-like -2.29849
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.20568
DSG2 desmoglein 2 -2.18281
SCAND1 SCAN domain containing 1 -2.17633
ICAM3 intercellular adhesion molecule 3 -2.11275
RPS5 ribosomal protein S5 -2.1
RBM15 RNA binding motif protein 15 -2.07885
HMG20B high mobility group 20B -2.01358