CRCGN010_HEPG2_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-ddt 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

117 genes differentially expressed following the CRCGN010_HEPG2_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.77188
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.40798
UBQLN2 ubiquilin 2 4.30368
GAA glucosidase, alpha; acid 4.23805
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.14478
C2CD2 C2 calcium-dependent domain containing 2 3.81228
PPARG peroxisome proliferator-activated receptor gamma 3.71011
MVP major vault protein 3.57653
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.46444
STIMATE STIM activating enhancer 3.39738
CXCL2 chemokine (C-X-C motif) ligand 2 3.34558
INPP1 inositol polyphosphate-1-phosphatase 3.33062
DYNLT3 dynein, light chain, Tctex-type 3 3.13599
ADRB2 adrenoceptor beta 2, surface 3.01708
NPDC1 neural proliferation, differentiation and control, 1 2.98098
EPN2 epsin 2 2.97971
GSTZ1 glutathione S-transferase zeta 1 2.93122
EVL Enah/Vasp-like 2.8933
SQSTM1 sequestosome 1 2.80139
MYLK myosin light chain kinase 2.78045
STK10 serine/threonine kinase 10 2.72608
PLS1 plastin 1 2.57072
E2F2 E2F transcription factor 2 2.54641
SFTPB surfactant protein B 2.49108
VGLL4 vestigial-like family member 4 2.49072
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.45265
HLA-DMA major histocompatibility complex, class II, DM alpha 2.45155
UGDH UDP-glucose 6-dehydrogenase 2.42877
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.42571
GPER1 G protein-coupled estrogen receptor 1 2.37927
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.36676
MAST2 microtubule associated serine/threonine kinase 2 2.34283
LPAR2 lysophosphatidic acid receptor 2 2.33065
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.32456
HOXC5 homeobox C5 2.30755
CRYGB crystallin, gamma B 2.30662
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.30394
RAP1GAP RAP1 GTPase activating protein 2.28929
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.2777
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.26613
RAB21 RAB21, member RAS oncogene family 2.26091
AMH anti-Mullerian hormone 2.23347
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.22602
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.22192
TIMP2 TIMP metallopeptidase inhibitor 2 2.21788
CEMIP2 cell migration inducing hyaluronidase 2 2.1978
NPY4R2 neuropeptide Y receptor Y4-2 2.15545
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.15439
EXTL1 exostosin-like glycosyltransferase 1 2.14781
POU4F1 POU class 4 homeobox 1 2.14356
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.13818
LSAMP limbic system-associated membrane protein 2.13717
GSTT4 glutathione S-transferase theta 4 2.12662
PEX5L peroxisomal biogenesis factor 5-like 2.08888
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.08074
NALF1 NALCN channel auxiliary factor 1 2.07619
NMU neuromedin U 2.0746
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.06291
TBXA2R thromboxane A2 receptor 2.05597
CRYGA crystallin, gamma A 2.04397
RBM15B RNA binding motif protein 15B 2.04357
CDON cell adhesion associated, oncogene regulated 2.03758
CCDC87 coiled-coil domain containing 87 2.03329
EPHA3 EPH receptor A3 2.03196
MAP7 microtubule-associated protein 7 2.02392
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.01672
PLXNB3 plexin B3 2.01582
OR7A5 olfactory receptor, family 7, subfamily A, member 5 2.01127
TIAM1 T-cell lymphoma invasion and metastasis 1 2.0015
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.00132
COL9A1 collagen, type IX, alpha 1 2.0007

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.50548
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.45275
HAT1 histone acetyltransferase 1 -4.89848
ADI1 acireductone dioxygenase 1 -4.7816
PSRC1 proline/serine-rich coiled-coil 1 -4.56064
CDC20 cell division cycle 20 -4.4511
TLR4 toll-like receptor 4 -4.31401
CDC25B cell division cycle 25B -4.22991
CCNB2 cyclin B2 -4.13458
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.72982
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.63281
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.5626
TCTN1 tectonic family member 1 -3.52717
LDHD lactate dehydrogenase D -3.44414
PCCB propionyl CoA carboxylase, beta polypeptide -3.44125
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.29729
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.24839
LAP3 leucine aminopeptidase 3 -3.10286
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.03077
NCK1 NCK adaptor protein 1 -2.90472
DNM1L dynamin 1-like -2.83374
NGRN neugrin, neurite outgrowth associated -2.75747
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.72563
TM9SF3 transmembrane 9 superfamily member 3 -2.71261
MRPS2 mitochondrial ribosomal protein S2 -2.60053
ZNF586 zinc finger protein 586 -2.5958
LBR lamin B receptor -2.55121
ITGB1BP1 integrin beta 1 binding protein 1 -2.54158
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.53279
RNF167 ring finger protein 167 -2.46915
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.46649
RFC2 replication factor C (activator 1) 2, 40kDa -2.44706
MELK maternal embryonic leucine zipper kinase -2.40059
PECR peroxisomal trans-2-enoyl-CoA reductase -2.35643
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.30174
PLK1 polo-like kinase 1 -2.28374
CD58 CD58 molecule -2.26976
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.24859
MYCBP MYC binding protein -2.20291
ICAM3 intercellular adhesion molecule 3 -2.19188
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.16658
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.15701
CHIC2 cysteine-rich hydrophobic domain 2 -2.11268
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.10806
CDK1 cyclin-dependent kinase 1 -2.03255
CAPRIN2 caprin family member 2 -2.02415