CRCGN010_HEPG2_24H:G02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-ddt 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN010_HEPG2_24H:G02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.67029
MCM3 minichromosome maintenance complex component 3 4.38302
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4.22583
PNKP polynucleotide kinase 3'-phosphatase 4.00326
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.62955
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.62597
CSK c-src tyrosine kinase 3.60319
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.57795
RPP38 ribonuclease P/MRP 38kDa subunit 3.51816
SATB1 SATB homeobox 1 3.45852
LSR lipolysis stimulated lipoprotein receptor 3.35608
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.31958
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.28199
SLC75A1 solute carrier family 75 member 1 3.26991
WDR7 WD repeat domain 7 3.26197
PRKCH protein kinase C, eta 3.20037
TIMP2 TIMP metallopeptidase inhibitor 2 3.15734
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.06025
MYLK myosin light chain kinase 3.05653
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.05123
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.9491
RAB21 RAB21, member RAS oncogene family 2.9174
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.84871
MICALL1 MICAL-like 1 2.83328
MINDY1 MINDY lysine 48 deubiquitinase 1 2.82269
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.80475
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.79702
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.74556
BACE2 beta-site APP-cleaving enzyme 2 2.74483
NOSIP nitric oxide synthase interacting protein 2.71874
CXCL2 chemokine (C-X-C motif) ligand 2 2.70991
TEX10 testis expressed 10 2.69499
ABHD6 abhydrolase domain containing 6 2.65381
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.65269
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.60145
SHB Src homology 2 domain containing adaptor protein B 2.58726
MN1 meningioma (disrupted in balanced translocation) 1 2.54142
MTERF3 mitochondrial transcription termination factor 3 2.51404
VAV3 vav 3 guanine nucleotide exchange factor 2.51009
PTK2 protein tyrosine kinase 2 2.49772
MAP7 microtubule-associated protein 7 2.46428
HSPA8 heat shock 70kDa protein 8 2.46202
RAB4A RAB4A, member RAS oncogene family 2.45325
CBR3 carbonyl reductase 3 2.44739
AXIN1 axin 1 2.43794
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.41948
HEBP1 heme binding protein 1 2.40704
CHMP6 charged multivesicular body protein 6 2.39647
ASB7 ankyrin repeat and SOCS box containing 7 2.37643
RRAGA Ras-related GTP binding A 2.36341
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.25018
COPS7A COP9 signalosome subunit 7A 2.20712
NNT nicotinamide nucleotide transhydrogenase 2.20414
TP53BP1 tumor protein p53 binding protein 1 2.18121
HMOX1 heme oxygenase 1 2.17195
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 2.15459
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.15362
ST18 suppression of tumorigenicity 18, zinc finger 2.12479
CDC45 cell division cycle 45 2.1213
ERCC4 excision repair cross-complementation group 4 2.10122
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.09107
SIM2 single-minded family bHLH transcription factor 2 2.08679
MCUR1 mitochondrial calcium uniporter regulator 1 2.06953
HLA-DMA major histocompatibility complex, class II, DM alpha 2.06802
PRR15L proline rich 15-like 2.06598
CREG1 cellular repressor of E1A-stimulated genes 1 2.03863
NFIL3 nuclear factor, interleukin 3 regulated 2.00783

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.58579
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.55857
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.8847
ZMIZ1 zinc finger, MIZ-type containing 1 -4.28625
NUP85 nucleoporin 85kDa -3.92596
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.79144
ISOC1 isochorismatase domain containing 1 -3.77842
CCNB2 cyclin B2 -3.67702
TLR4 toll-like receptor 4 -3.61207
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.58837
MRPS16 mitochondrial ribosomal protein S16 -3.55285
ANKRD10 ankyrin repeat domain 10 -3.48537
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.46251
HAT1 histone acetyltransferase 1 -3.4354
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.37052
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.27347
PUF60 poly-U binding splicing factor 60KDa -3.2667
SCAND1 SCAN domain containing 1 -3.25424
TM9SF3 transmembrane 9 superfamily member 3 -3.14697
FASTKD5 FAST kinase domains 5 -3.01158
CRYZ crystallin, zeta (quinone reductase) -2.93997
TCTN1 tectonic family member 1 -2.92131
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.9015
PCNA proliferating cell nuclear antigen -2.88328
DDIT4 DNA-damage-inducible transcript 4 -2.87626
CAB39 calcium binding protein 39 -2.83651
CD320 CD320 molecule -2.83154
GTPBP8 GTP-binding protein 8 (putative) -2.72604
CGRRF1 cell growth regulator with ring finger domain 1 -2.72451
HMG20B high mobility group 20B -2.68043
PEG10 paternally expressed 10 -2.65939
LDHD lactate dehydrogenase D -2.64026
WASHC4 WASH complex subunit 4 -2.6323
GLOD4 glyoxalase domain containing 4 -2.6111
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.60847
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.58243
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.47154
RFC2 replication factor C (activator 1) 2, 40kDa -2.42368
TM9SF2 transmembrane 9 superfamily member 2 -2.41999
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.39489
SMNDC1 survival motor neuron domain containing 1 -2.38559
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.28114
PDZD2 PDZ domain containing 2 -2.24664
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.1804
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.15843
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.15744
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.06519
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.05403
SCRIB scribbled planar cell polarity protein -2.04708
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.02825
UBE2C ubiquitin-conjugating enzyme E2C -2.02609
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.02017