CRCGN010_HEPG2_24H:G03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-ddt 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:G03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.70753
LCN2 lipocalin 2 8.66996
DYNLT3 dynein, light chain, Tctex-type 3 7.07161
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.08848
MSRA methionine sulfoxide reductase A 4.83317
ATP11B ATPase, class VI, type 11B 4.76655
BACE2 beta-site APP-cleaving enzyme 2 4.75655
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.30194
PRR15L proline rich 15-like 4.27145
EPHB2 EPH receptor B2 4.24666
GSTZ1 glutathione S-transferase zeta 1 4.20455
KLHL9 kelch-like family member 9 4.19933
CXCL2 chemokine (C-X-C motif) ligand 2 3.57045
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.46732
CCL2 chemokine (C-C motif) ligand 2 3.466
NOTCH1 notch 1 3.33888
RPP38 ribonuclease P/MRP 38kDa subunit 3.32855
CHMP6 charged multivesicular body protein 6 3.2249
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.1891
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.01744
PEX11A peroxisomal biogenesis factor 11 alpha 2.99569
LPAR2 lysophosphatidic acid receptor 2 2.96
PFKL phosphofructokinase, liver 2.73845
GPER1 G protein-coupled estrogen receptor 1 2.68751
TEX10 testis expressed 10 2.63408
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.57946
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.43885
PGAM4 phosphoglycerate mutase family member 4 2.34149
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.28547
NMU neuromedin U 2.27536
TIAM1 T-cell lymphoma invasion and metastasis 1 2.25588
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.17234
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.16363
SSBP2 single-stranded DNA binding protein 2 2.16001
TPD52L2 tumor protein D52-like 2 2.13592
DEFA6 defensin, alpha 6, Paneth cell-specific 2.13269
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.1192
EGF epidermal growth factor 2.0913
FLRT1 fibronectin leucine rich transmembrane protein 1 2.06954
DPEP1 dipeptidase 1 (renal) 2.03967
CHN1 chimerin 1 2.03732

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.68164
LDHD lactate dehydrogenase D -6.43684
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.96572
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.08841
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
PCNA proliferating cell nuclear antigen -4.93765
CDC20 cell division cycle 20 -4.93215
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.51262
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.14363
CCNB2 cyclin B2 -3.59955
NT5DC2 5'-nucleotidase domain containing 2 -3.48587
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.36639
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.72723
SNX11 sorting nexin 11 -2.71381
CSK c-src tyrosine kinase -2.44845
ITGB1BP1 integrin beta 1 binding protein 1 -2.37862
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.36994
RNF167 ring finger protein 167 -2.34605
CA4 carbonic anhydrase IV -2.15625
CCNH cyclin H -2.15225
TM9SF3 transmembrane 9 superfamily member 3 -2.04366
DCK deoxycytidine kinase -2.01023