CRCGN010_HEPG2_24H:G04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-ddt 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN010_HEPG2_24H:G04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.37071
ATP11B ATPase, class VI, type 11B 5.10866
NANOS3 nanos homolog 3 (Drosophila) 4.93852
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.9199
EPHB2 EPH receptor B2 4.89464
C2CD2 C2 calcium-dependent domain containing 2 4.7346
CCDC92 coiled-coil domain containing 92 4.68402
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.47829
CXCL2 chemokine (C-X-C motif) ligand 2 4.41702
GPER1 G protein-coupled estrogen receptor 1 4.24205
EPN2 epsin 2 4.21235
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.05115
VGLL4 vestigial-like family member 4 3.92201
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.91134
CARMIL1 capping protein regulator and myosin 1 linker 1 3.44142
MICALL1 MICAL-like 1 3.19701
NOTCH1 notch 1 3.19086
GATA3 GATA binding protein 3 3.17103
CSK c-src tyrosine kinase 3.00316
HLA-DRA major histocompatibility complex, class II, DR alpha 2.97563
CCNF cyclin F 2.8434
PLSCR3 phospholipid scramblase 3 2.70757
DYNLT3 dynein, light chain, Tctex-type 3 2.69102
COL9A3 collagen, type IX, alpha 3 2.65473
CCL2 chemokine (C-C motif) ligand 2 2.62352
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.62224
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.61902
CYCS cytochrome c, somatic 2.52907
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.38991
SSBP2 single-stranded DNA binding protein 2 2.37908
NOSIP nitric oxide synthase interacting protein 2.36794
ADIRF adipogenesis regulatory factor 2.34146
EPHB3 EPH receptor B3 2.32404
GPATCH8 G patch domain containing 8 2.31019
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.30745
FOXC2 forkhead box C2 2.28035
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.26308
CIAO3 cytosolic iron-sulfur assembly component 3 2.236
CEP57 centrosomal protein 57kDa 2.20136
PYCR1 pyrroline-5-carboxylate reductase 1 2.17207
CD70 CD70 molecule 2.14804
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.14622
CD40 CD40 molecule, TNF receptor superfamily member 5 2.12234
THBD thrombomodulin 2.10753
ITGA10 integrin, alpha 10 2.10261
HSPA8 heat shock 70kDa protein 8 2.0865
PLD3 phospholipase D family, member 3 2.06624
A4GALT alpha 1,4-galactosyltransferase 2.06518
LMO7 LIM domain 7 2.05617
RHOBTB2 Rho-related BTB domain containing 2 2.05494
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.0487
MPZL2 myelin protein zero-like 2 2.04859
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 2.04513
ACAN aggrecan 2.02917
FRY furry homolog (Drosophila) 2.0077

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.59908
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.47288
FBXL12 F-box and leucine-rich repeat protein 12 -6.07108
SLC35F2 solute carrier family 35, member F2 -5.87406
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.28497
MRPS16 mitochondrial ribosomal protein S16 -4.94376
TRIB3 tribbles pseudokinase 3 -4.94283
MRPS2 mitochondrial ribosomal protein S2 -4.92644
LDHD lactate dehydrogenase D -4.88435
OXA1L oxidase (cytochrome c) assembly 1-like -4.81914
ADI1 acireductone dioxygenase 1 -4.38224
CHMP4B charged multivesicular body protein 4B -4.13156
UBE3C ubiquitin protein ligase E3C -3.89666
NRIP1 nuclear receptor interacting protein 1 -3.46858
TRAPPC3 trafficking protein particle complex 3 -3.36496
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.32583
RFC2 replication factor C (activator 1) 2, 40kDa -3.27909
HMG20B high mobility group 20B -3.25107
SPAG4 sperm associated antigen 4 -2.78098
LYSET lysosomal enzyme trafficking factor -2.76554
MAPK13 mitogen-activated protein kinase 13 -2.73002
MRPS15 mitochondrial ribosomal protein S15 -2.55722
FBXO7 F-box protein 7 -2.52765
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.38694
TMEM187 transmembrane protein 187 -2.3304
COQ4 coenzyme Q4 -2.28609
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.23965
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.18151
PCNA proliferating cell nuclear antigen -2.18125
FASTKD5 FAST kinase domains 5 -2.18021
ASB6 ankyrin repeat and SOCS box containing 6 -2.16952
ITGB1BP1 integrin beta 1 binding protein 1 -2.15703
CDC25B cell division cycle 25B -2.09208
CNN1 calponin 1, basic, smooth muscle -2.08702
SRPX sushi-repeat containing protein, X-linked -2.05797
E2F6 E2F transcription factor 6 -2.05585
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.02631
CLTB clathrin, light chain B -2.02066
NRDC nardilysin convertase -2.01478
DDTL D-dopachrome tautomerase-like -2.00237