CRCGN010_HEPG2_24H:G05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-ddt 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN010_HEPG2_24H:G05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.30519
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.2789
PPARG peroxisome proliferator-activated receptor gamma 4.89585
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.88293
RPP38 ribonuclease P/MRP 38kDa subunit 4.66453
MAP7 microtubule-associated protein 7 4.42434
ZFP36 ZFP36 ring finger protein 4.10825
CCNA1 cyclin A1 3.00119
NMU neuromedin U 2.94715
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.64477
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.57157
CTSL cathepsin L 2.51147
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.39643
AMDHD2 amidohydrolase domain containing 2 2.3793
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.37201
CIAO3 cytosolic iron-sulfur assembly component 3 2.36715
ABHD6 abhydrolase domain containing 6 2.34734
HLA-DRA major histocompatibility complex, class II, DR alpha 2.3203
MYLK myosin light chain kinase 2.31777
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.26694
JADE2 jade family PHD finger 2 2.23771
CCDC51 coiled-coil domain containing 51 2.10422
ADGRE5 adhesion G protein-coupled receptor E5 2.07973
MTPAP mitochondrial poly(A) polymerase 2.0474
METTL18 methyltransferase like 18 2.04427
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.02071
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.01467

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -6.18525
GNAS GNAS complex locus -5.46891
PCNA proliferating cell nuclear antigen -5.15576
CCNB2 cyclin B2 -4.6852
RFC2 replication factor C (activator 1) 2, 40kDa -3.30066
WASHC4 WASH complex subunit 4 -2.94118
OXA1L oxidase (cytochrome c) assembly 1-like -2.86098
NCK1 NCK adaptor protein 1 -2.46511
GLOD4 glyoxalase domain containing 4 -2.37162
EIF5 eukaryotic translation initiation factor 5 -2.34863
BCORL1 BCL6 corepressor-like 1 -2.3232
MOXD1 monooxygenase, DBH-like 1 -2.24464
VAT1 vesicle amine transport 1 -2.24399
TBX2 T-box 2 -2.19527
PDZD2 PDZ domain containing 2 -2.18351
LMTK1 lemur tail kinase 1 -2.15391
RBM15B RNA binding motif protein 15B -2.10716
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.07821