CRCGN010_HEPG2_24H:G07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenyl-b-naphthylamine 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

198 genes differentially expressed following the CRCGN010_HEPG2_24H:G07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.90327
GSTZ1 glutathione S-transferase zeta 1 6.53327
E2F2 E2F transcription factor 2 6.34679
TXNRD1 thioredoxin reductase 1 6.19184
EPHB2 EPH receptor B2 5.71186
SQSTM1 sequestosome 1 5.20575
UGDH UDP-glucose 6-dehydrogenase 4.65664
VAT1 vesicle amine transport 1 4.40242
PNKP polynucleotide kinase 3'-phosphatase 4.26357
HMOX1 heme oxygenase 1 4.21626
RAB21 RAB21, member RAS oncogene family 4.14867
LCN2 lipocalin 2 3.9873
SQOR sulfide quinone oxidoreductase 3.98237
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.93627
CSK c-src tyrosine kinase 3.93325
UBQLN2 ubiquilin 2 3.86977
RAP1GAP RAP1 GTPase activating protein 3.62062
ABHD4 abhydrolase domain containing 4 3.58208
MVP major vault protein 3.53783
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.44261
SLC25A46 solute carrier family 25, member 46 3.418
EVL Enah/Vasp-like 3.38731
NOTCH1 notch 1 3.37708
CXCL2 chemokine (C-X-C motif) ligand 2 3.26904
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.24128
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.21361
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.19718
HKDC1 hexokinase domain containing 1 3.00338
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.93808
PRSS16 protease, serine, 16 (thymus) 2.93255
KIFBP kinesin family binding protein 2.92743
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.91129
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.8254
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.79512
BZW2 basic leucine zipper and W2 domains 2 2.79112
STIMATE STIM activating enhancer 2.77495
BCOR BCL6 corepressor 2.73165
GLRX glutaredoxin (thioltransferase) 2.71152
TXNL4B thioredoxin-like 4B 2.66184
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.58114
PXMP2 peroxisomal membrane protein 2, 22kDa 2.51453
CCL24 chemokine (C-C motif) ligand 24 2.47602
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.4508
NPDC1 neural proliferation, differentiation and control, 1 2.44035
CCL15 chemokine (C-C motif) ligand 15 2.43594
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.43146
VAV3 vav 3 guanine nucleotide exchange factor 2.39698
HPN hepsin 2.37721
FZD7 frizzled class receptor 7 2.36035
MMP3 matrix metallopeptidase 3 2.34575
GCLC glutamate-cysteine ligase, catalytic subunit 2.34179
AARSD1 alanyl-tRNA synthetase domain containing 1 2.3337
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.32269
SLC75A1 solute carrier family 75 member 1 2.31921
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.317
NT5M 5',3'-nucleotidase, mitochondrial 2.31684
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.30747
RAX retina and anterior neural fold homeobox 2.29677
NUCB2 nucleobindin 2 2.28714
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.28619
HEBP1 heme binding protein 1 2.28319
SMIM40 small integral membrane protein 40 2.2808
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.27488
RPP38 ribonuclease P/MRP 38kDa subunit 2.27071
TIAM1 T-cell lymphoma invasion and metastasis 1 2.26886
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.25304
NOSIP nitric oxide synthase interacting protein 2.23275
NADSYN1 NAD synthetase 1 2.21309
ABHD6 abhydrolase domain containing 6 2.20083
TRIM15 tripartite motif containing 15 2.19448
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.19208
KDM5C lysine (K)-specific demethylase 5C 2.18748
CPZ carboxypeptidase Z 2.1821
ATOH1 atonal homolog 1 (Drosophila) 2.15821
JUN jun proto-oncogene 2.1557
DIPK1A divergent protein kinase domain 1A 2.14649
TEX10 testis expressed 10 2.14316
LRRC42 leucine rich repeat containing 42 2.13976
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.12878
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.125
GUCY2C guanylate cyclase 2C 2.10254
ALAS1 5'-aminolevulinate synthase 1 2.09825
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.09052
STAP2 signal transducing adaptor family member 2 2.08186
FGGY FGGY carbohydrate kinase domain containing 2.07973
PLEK2 pleckstrin 2 2.07797
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.07662
MAST2 microtubule associated serine/threonine kinase 2 2.07213
CLCA1 chloride channel accessory 1 2.06778
NOL12 nucleolar protein 12 2.06753
CDX1 caudal type homeobox 1 2.06014
PCDHB11 protocadherin beta 11 2.05731
DAO D-amino-acid oxidase 2.0504
SMIM5 small integral membrane protein 5 2.04072
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.04051
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.04025
CELA2B chymotrypsin-like elastase family, member 2B 2.038
ALPL alkaline phosphatase, liver/bone/kidney 2.02611
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.01948
INO80D INO80 complex subunit D 2.0148
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.00894
IQCB1 IQ motif containing B1 2.00829
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.00805
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.00622
ARHGAP4 Rho GTPase activating protein 4 2.00424

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -6.93702
PCNA proliferating cell nuclear antigen -6.6841
GNAS GNAS complex locus -6.6635
CDC20 cell division cycle 20 -6.04619
PEG10 paternally expressed 10 -5.44695
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.3819
PSRC1 proline/serine-rich coiled-coil 1 -5.11021
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.94115
VDAC1 voltage-dependent anion channel 1 -4.80323
TUBB6 tubulin, beta 6 class V -4.53761
YME1L1 YME1-like 1 ATPase -4.24484
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.98845
ADI1 acireductone dioxygenase 1 -3.98363
OXA1L oxidase (cytochrome c) assembly 1-like -3.83459
AURKB aurora kinase B -3.79206
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.74331
TRIB3 tribbles pseudokinase 3 -3.58007
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.55349
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.49888
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.45348
CD58 CD58 molecule -3.43903
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.43504
KDM3A lysine (K)-specific demethylase 3A -3.43157
MRPS2 mitochondrial ribosomal protein S2 -3.4293
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.41484
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.31316
PLK1 polo-like kinase 1 -3.29225
TLR4 toll-like receptor 4 -3.28691
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.27448
MELK maternal embryonic leucine zipper kinase -3.22733
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.20979
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.18388
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.17592
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.13686
PCCB propionyl CoA carboxylase, beta polypeptide -3.05942
KIF14 kinesin family member 14 -3.01179
TCTN1 tectonic family member 1 -2.98921
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.90988
ARID5B AT rich interactive domain 5B (MRF1-like) -2.83725
TLCD3A TLC domain containing 3A -2.83491
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.77857
PHACTR1 phosphatase and actin regulator 1 -2.66988
SOAT2 sterol O-acyltransferase 2 -2.66393
SLC35F2 solute carrier family 35, member F2 -2.66205
GID8 GID complex subunit 8 -2.64168
UBE2C ubiquitin-conjugating enzyme E2C -2.61378
ALDOC aldolase C, fructose-bisphosphate -2.53247
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.50573
WASHC4 WASH complex subunit 4 -2.50279
ABHD17A abhydrolase domain containing 17A -2.49946
GGCT gamma-glutamylcyclotransferase -2.42577
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.40888
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.38272
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.35568
BET1 Bet1 golgi vesicular membrane trafficking protein -2.3472
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.33362
ZNF274 zinc finger protein 274 -2.29964
RPLP2 ribosomal protein, large, P2 -2.29336
MRPS33 mitochondrial ribosomal protein S33 -2.28288
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.24412
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.2119
AURKA aurora kinase A -2.19681
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.19308
EDN1 endothelin 1 -2.17881
TSPAN3 tetraspanin 3 -2.17589
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.17342
RPS11 ribosomal protein S11 -2.17156
HEATR1 HEAT repeat containing 1 -2.15738
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.1459
NGRN neugrin, neurite outgrowth associated -2.1328
REPIN1 replication initiator 1 -2.13237
ZNF586 zinc finger protein 586 -2.12126
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.09947
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.09811
NELFCD negative elongation factor complex member C/D -2.09113
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.08192
MYL9 myosin, light chain 9, regulatory -2.08064
CALM3 calmodulin 3 (phosphorylase kinase, delta) -2.07877
CTSD cathepsin D -2.07855
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.07074
P4HB prolyl 4-hydroxylase, beta polypeptide -2.06932
RPL38 ribosomal protein L38 -2.05495
THEM6 thioesterase superfamily member 6 -2.05412
TPX2 TPX2, microtubule-associated -2.04657
NRIP1 nuclear receptor interacting protein 1 -2.03903
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.0384
ERP29 endoplasmic reticulum protein 29 -2.0285
CDK1 cyclin-dependent kinase 1 -2.02656
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.01432
HMGN1 high mobility group nucleosome binding domain 1 -2.01373
RPL12 ribosomal protein L12 -2.00279
ZC3H15 zinc finger CCCH-type containing 15 -2.00217