| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | phenyl-b-naphthylamine 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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70 genes differentially expressed following the CRCGN010_HEPG2_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NOTCH1 | notch 1 | 6.3497 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 6.15764 |
| GSTZ1 | glutathione S-transferase zeta 1 | 5.83872 |
| TXNRD1 | thioredoxin reductase 1 | 4.42844 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.75124 |
| NOSIP | nitric oxide synthase interacting protein | 3.63281 |
| HMOX1 | heme oxygenase 1 | 3.56778 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.54287 |
| SFTPB | surfactant protein B | 3.52426 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.47577 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.20342 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.17497 |
| PRKCQ | protein kinase C, theta | 3.17314 |
| CHMP6 | charged multivesicular body protein 6 | 3.15859 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.04116 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 3.03872 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.01589 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.01145 |
| UBQLN2 | ubiquilin 2 | 2.97345 |
| HDGFL3 | HDGF like 3 | 2.84895 |
| STIMATE | STIM activating enhancer | 2.70786 |
| MAP7 | microtubule-associated protein 7 | 2.67966 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.50243 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.48774 |
| VGLL4 | vestigial-like family member 4 | 2.37703 |
| DIPK1A | divergent protein kinase domain 1A | 2.37044 |
| STXBP2 | syntaxin binding protein 2 | 2.33284 |
| NENF | neudesin neurotrophic factor | 2.33013 |
| VAT1 | vesicle amine transport 1 | 2.26584 |
| SERHL2 | serine hydrolase-like 2 | 2.22291 |
| SRSF8 | serine/arginine-rich splicing factor 8 | 2.20569 |
| PRR15L | proline rich 15-like | 2.17668 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | 2.1696 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.08679 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.05571 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.04384 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 2.00801 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNM1L | dynamin 1-like | -6.84553 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -6.47483 |
| LDHD | lactate dehydrogenase D | -6.32 |
| CCNB2 | cyclin B2 | -5.8842 |
| ZNF586 | zinc finger protein 586 | -5.62754 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -5.31037 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.98291 |
| THAP11 | THAP domain containing 11 | -3.72409 |
| NGRN | neugrin, neurite outgrowth associated | -3.53839 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.45806 |
| PEG10 | paternally expressed 10 | -3.37818 |
| VDAC1 | voltage-dependent anion channel 1 | -3.27494 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.24372 |
| CD320 | CD320 molecule | -3.17009 |
| CDC25B | cell division cycle 25B | -2.88074 |
| PCNA | proliferating cell nuclear antigen | -2.87323 |
| USP6NL | USP6 N-terminal like | -2.85288 |
| FAIM | Fas apoptotic inhibitory molecule | -2.83347 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.82098 |
| EXT1 | exostosin glycosyltransferase 1 | -2.76671 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.60228 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.53559 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.34924 |
| RPS5 | ribosomal protein S5 | -2.25878 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.19149 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -2.17059 |
| SESN1 | sestrin 1 | -2.1273 |
| TOR1A | torsin family 1, member A (torsin A) | -2.10053 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.08288 |
| TCTN1 | tectonic family member 1 | -2.07846 |
| TES | testin LIM domain protein | -2.07098 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.04391 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.01972 |
