CRCGN010_HEPG2_24H:G11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenyl-b-naphthylamine 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN010_HEPG2_24H:G11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.72378
PRR15L proline rich 15-like 5.1454
H2BC12 H2B clustered histone 12 4.63448
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.5767
CHN1 chimerin 1 4.34447
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.21952
BLMH bleomycin hydrolase 3.84725
CIAO3 cytosolic iron-sulfur assembly component 3 3.82801
GPATCH8 G patch domain containing 8 3.54411
E2F2 E2F transcription factor 2 3.54072
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.5019
UBQLN2 ubiquilin 2 3.47614
CARMIL1 capping protein regulator and myosin 1 linker 1 3.31671
CHMP6 charged multivesicular body protein 6 3.08897
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.06803
ABHD4 abhydrolase domain containing 4 3.03768
FZD7 frizzled class receptor 7 2.94482
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.94099
RXYLT1 ribitol xylosyltransferase 1 2.9097
GARRE1 granule associated Rac and RHOG effector 1 2.88271
MEST mesoderm specific transcript 2.76958
CRTAP cartilage associated protein 2.70573
LCN2 lipocalin 2 2.6587
GSTZ1 glutathione S-transferase zeta 1 2.64714
VGLL4 vestigial-like family member 4 2.63891
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.38304
HOXA10 homeobox A10 2.36596
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.30684
GATA3 GATA binding protein 3 2.28239
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.19155
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.12842
DKKL1 dickkopf-like 1 2.1204
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.11996
ADGRG1 adhesion G protein-coupled receptor G1 2.11764
PPARG peroxisome proliferator-activated receptor gamma 2.09658
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.09055
ATP9B ATPase, class II, type 9B 2.08842
PROP1 PROP paired-like homeobox 1 2.07254
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.05523
MELK maternal embryonic leucine zipper kinase 2.03475
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.01186

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.3413
MAPK13 mitogen-activated protein kinase 13 -4.93065
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.76632
OXA1L oxidase (cytochrome c) assembly 1-like -4.58318
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.75465
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.5707
KDM3A lysine (K)-specific demethylase 3A -3.37157
CHMP4B charged multivesicular body protein 4B -3.26204
PCCB propionyl CoA carboxylase, beta polypeptide -3.01423
EIF5 eukaryotic translation initiation factor 5 -2.96355
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.90525
RAI14 retinoic acid induced 14 -2.6605
FGFR4 fibroblast growth factor receptor 4 -2.62709
HEATR1 HEAT repeat containing 1 -2.60561
PTPRK protein tyrosine phosphatase, receptor type, K -2.52124
ZNF586 zinc finger protein 586 -2.48337
CCNB1 cyclin B1 -2.4425
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.43235
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.3886
ETFB electron-transfer-flavoprotein, beta polypeptide -2.34555
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -2.27178
LAMP5 lysosomal-associated membrane protein family, member 5 -2.23506
DNM1L dynamin 1-like -2.19264
RBM34 RNA binding motif protein 34 -2.11358
TLCD3A TLC domain containing 3A -2.09078
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.04974