| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | withaferin-a 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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166 genes differentially expressed following the CRCGN010_HEPG2_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GSTZ1 | glutathione S-transferase zeta 1 | 9.07134 |
| TXNRD1 | thioredoxin reductase 1 | 8.20749 |
| HMOX1 | heme oxygenase 1 | 7.63477 |
| ABHD4 | abhydrolase domain containing 4 | 7.15061 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.72896 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.5692 |
| ADRB2 | adrenoceptor beta 2, surface | 6.41979 |
| MCOLN1 | mucolipin 1 | 6.32037 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.19092 |
| FOSL1 | FOS-like antigen 1 | 5.43558 |
| H2BC12 | H2B clustered histone 12 | 5.12134 |
| SQSTM1 | sequestosome 1 | 4.7442 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.55905 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 4.26518 |
| KEAP1 | kelch-like ECH-associated protein 1 | 4.18317 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 4.11968 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.05843 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 4.05161 |
| CDC20 | cell division cycle 20 | 4.0217 |
| NMU | neuromedin U | 3.97461 |
| ZW10 | zw10 kinetochore protein | 3.88583 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.78619 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 3.7168 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.48384 |
| UBQLN2 | ubiquilin 2 | 3.47854 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.46702 |
| KLHL21 | kelch-like family member 21 | 3.36539 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.36276 |
| H2BC21 | H2B clustered histone 21 | 3.35082 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 3.30761 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.30185 |
| TUBB6 | tubulin, beta 6 class V | 3.27234 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 3.25668 |
| MVP | major vault protein | 3.23544 |
| LAGE3 | L antigen family, member 3 | 3.08992 |
| STXBP1 | syntaxin binding protein 1 | 2.99661 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.99173 |
| ABHD6 | abhydrolase domain containing 6 | 2.98731 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 2.93322 |
| CHN1 | chimerin 1 | 2.8772 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.83459 |
| TMEM109 | transmembrane protein 109 | 2.823 |
| STIMATE | STIM activating enhancer | 2.80134 |
| EMC3 | ER membrane protein complex subunit 3 | 2.77949 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.77171 |
| HSPA1A | heat shock 70kDa protein 1A | 2.75936 |
| MEST | mesoderm specific transcript | 2.6943 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.68851 |
| GPC1 | glypican 1 | 2.68831 |
| MAMLD1 | mastermind-like domain containing 1 | 2.65447 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.60469 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.60196 |
| BAG3 | BCL2-associated athanogene 3 | 2.60174 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.58764 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.55439 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.50829 |
| CBR1 | carbonyl reductase 1 | 2.48612 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.47565 |
| CDC45 | cell division cycle 45 | 2.4422 |
| GSR | glutathione reductase | 2.40434 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.39992 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.39302 |
| TMEM50A | transmembrane protein 50A | 2.3755 |
| NPTXR | neuronal pentraxin receptor | 2.33166 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.27592 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.27281 |
| BAG2 | BCL2-associated athanogene 2 | 2.25876 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.24876 |
| SPANXB1 | SPANX family, member B1 | 2.21356 |
| HTRA1 | HtrA serine peptidase 1 | 2.20366 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 2.20104 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 2.16022 |
| FMO3 | flavin containing monooxygenase 3 | 2.15306 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.13558 |
| WNT5B | wingless-type MMTV integration site family, member 5B | 2.11962 |
| GATA2 | GATA binding protein 2 | 2.11256 |
| CTSL | cathepsin L | 2.08104 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.06019 |
| RAB21 | RAB21, member RAS oncogene family | 2.05912 |
| ACVR2A | activin A receptor, type IIA | 2.05851 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | 2.0382 |
| MICALL1 | MICAL-like 1 | 2.03612 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.02543 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -9.6455 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -7.81793 |
| TRIB3 | tribbles pseudokinase 3 | -7.41345 |
| COG2 | component of oligomeric golgi complex 2 | -6.69036 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -6.55882 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -6.41997 |
| ZNF586 | zinc finger protein 586 | -6.00692 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -5.13922 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.82329 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -4.6618 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.59896 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -4.15694 |
| CCDC86 | coiled-coil domain containing 86 | -4.02436 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -4.01762 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.9914 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.96172 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.96061 |
| ADI1 | acireductone dioxygenase 1 | -3.95665 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.93663 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.8789 |
| LDHD | lactate dehydrogenase D | -3.85543 |
| PGM1 | phosphoglucomutase 1 | -3.80426 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.74481 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.68019 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.58918 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.58191 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -3.55615 |
| NGRN | neugrin, neurite outgrowth associated | -3.5383 |
| TRAP1 | TNF receptor-associated protein 1 | -3.4918 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.4308 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.21978 |
| NISCH | nischarin | -3.1961 |
| HYOU1 | hypoxia up-regulated 1 | -3.19306 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -3.18507 |
| NNT | nicotinamide nucleotide transhydrogenase | -3.11098 |
| PLK1 | polo-like kinase 1 | -3.06975 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.02879 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -3.00468 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.97163 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.92105 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | -2.89309 |
| STMN1 | stathmin 1 | -2.88775 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.82879 |
| DSG2 | desmoglein 2 | -2.80882 |
| DCK | deoxycytidine kinase | -2.76482 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.76321 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.70983 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.67472 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -2.65326 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -2.59542 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.58239 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.57135 |
| PYCARD | PYD and CARD domain containing | -2.54921 |
| TSPAN6 | tetraspanin 6 | -2.54204 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.52048 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.49582 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.47924 |
| CRTAP | cartilage associated protein | -2.45563 |
| S100A1 | S100 calcium binding protein A1 | -2.44046 |
| ICAM1 | intercellular adhesion molecule 1 | -2.39444 |
| TM4SF5 | transmembrane 4 L six family member 5 | -2.3822 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -2.34946 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.31376 |
| GPR137B | G protein-coupled receptor 137B | -2.27972 |
| SOAT2 | sterol O-acyltransferase 2 | -2.27839 |
| MACF1 | microtubule-actin crosslinking factor 1 | -2.2761 |
| MYO10 | myosin X | -2.2509 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.22701 |
| KIF14 | kinesin family member 14 | -2.22 |
| CD320 | CD320 molecule | -2.17876 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -2.16574 |
| TSPAN4 | tetraspanin 4 | -2.1592 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -2.12412 |
| HMGA2 | high mobility group AT-hook 2 | -2.114 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.10822 |
| STK25 | serine/threonine kinase 25 | -2.06371 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.06329 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -2.0568 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -2.05429 |
| NIP7 | NIP7, nucleolar pre-rRNA processing protein | -2.04991 |
| DUSP6 | dual specificity phosphatase 6 | -2.03124 |
| VEGFB | vascular endothelial growth factor B | -2.03036 |
| AGMAT | agmatine ureohydrolase (agmatinase) | -2.00586 |
