CRCGN010_HEPG2_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pirinixic-acid 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN010_HEPG2_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 7.55327
GSTZ1 glutathione S-transferase zeta 1 4.58574
PNKP polynucleotide kinase 3'-phosphatase 4.03882
LOC122526780 uncharacterized LOC122526780 4.01677
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.9774
ALDOC aldolase C, fructose-bisphosphate 3.94304
NOTCH1 notch 1 3.91708
BPHL biphenyl hydrolase-like (serine hydrolase) 3.84176
CYCS cytochrome c, somatic 3.76662
E2F2 E2F transcription factor 2 3.49641
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.2786
PPARG peroxisome proliferator-activated receptor gamma 2.95502
ECH1 enoyl CoA hydratase 1, peroxisomal 2.9317
MAP7 microtubule-associated protein 7 2.79351
HDGFL3 HDGF like 3 2.68058
TIAM1 T-cell lymphoma invasion and metastasis 1 2.55497
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.45761
LPAR2 lysophosphatidic acid receptor 2 2.36682
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.33644
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.24248
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.15186
KLHL9 kelch-like family member 9 2.05786
DYNLT3 dynein, light chain, Tctex-type 3 2.01853

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -7.42953
PCNA proliferating cell nuclear antigen -6.31824
YME1L1 YME1-like 1 ATPase -4.77742
TUBB6 tubulin, beta 6 class V -4.65894
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.36445
CCNB1 cyclin B1 -4.07575
ACOT9 acyl-CoA thioesterase 9 -3.98844
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.87596
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.74976
VDAC1 voltage-dependent anion channel 1 -3.62373
TRIB3 tribbles pseudokinase 3 -2.71174
ITGB1BP1 integrin beta 1 binding protein 1 -2.53628
CCNB2 cyclin B2 -2.43646
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.3467
PSRC1 proline/serine-rich coiled-coil 1 -2.30453
PRSS21 protease, serine, 21 (testisin) -2.26954
NRIP1 nuclear receptor interacting protein 1 -2.26167
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.23574
LDHD lactate dehydrogenase D -2.23367
RBM34 RNA binding motif protein 34 -2.07155
MAPK13 mitogen-activated protein kinase 13 -2.00859