CRCGN010_HEPG2_24H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pirinixic-acid 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN010_HEPG2_24H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
MAP7 microtubule-associated protein 7 7.62487
ATP11B ATPase, class VI, type 11B 5.69345
JADE2 jade family PHD finger 2 5.36597
LCN2 lipocalin 2 5.2647
EGF epidermal growth factor 5.23185
C2CD2 C2 calcium-dependent domain containing 2 5.0
ADGRE5 adhesion G protein-coupled receptor E5 4.9551
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.92935
BZW2 basic leucine zipper and W2 domains 2 4.91065
DYNLT3 dynein, light chain, Tctex-type 3 4.6785
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.653
PRR15L proline rich 15-like 4.52895
CIAO3 cytosolic iron-sulfur assembly component 3 4.25765
PNKP polynucleotide kinase 3'-phosphatase 4.24175
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.2124
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.09505
CGRRF1 cell growth regulator with ring finger domain 1 3.76715
KLHL9 kelch-like family member 9 3.728
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.5607
USP6NL USP6 N-terminal like 3.4892
GATA3 GATA binding protein 3 3.37685
TIAM1 T-cell lymphoma invasion and metastasis 1 3.31775
SIRT3 sirtuin 3 3.1367
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.99025
AXIN1 axin 1 2.85705
CD79B CD79b molecule, immunoglobulin-associated beta 2.6172
TPD52L2 tumor protein D52-like 2 2.61365
CHN1 chimerin 1 2.53325
EPHA3 EPH receptor A3 2.41785
COMP cartilage oligomeric matrix protein 2.4087
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.3095
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.2815
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.28137
JMJD4 jumonji domain containing 4 2.26345
CLDN4 claudin 4 2.2618
DCAF13 DDB1 and CUL4 associated factor 13 2.2487
DMTF1 cyclin D binding myb-like transcription factor 1 2.24242
BLK BLK proto-oncogene, Src family tyrosine kinase 2.23602
HLA-DRA major histocompatibility complex, class II, DR alpha 2.2196
NOD1 nucleotide-binding oligomerization domain containing 1 2.2008
RAB4A RAB4A, member RAS oncogene family 2.19865
GFI1 growth factor independent 1 transcription repressor 2.1911
TPD52L1 tumor protein D52-like 1 2.18745
RAB31 RAB31, member RAS oncogene family 2.185
S100G S100 calcium binding protein G 2.17035
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.1627
LDAF1 lipid droplet assembly factor 1 2.16085
ASCC3 activating signal cointegrator 1 complex subunit 3 2.1586
INSL4 insulin-like 4 (placenta) 2.1539
PHOX2A paired-like homeobox 2a 2.1306
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 2.12203
SUGCT succinyl-CoA:glutarate-CoA transferase 2.10825
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.09195
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.087
CYCS cytochrome c, somatic 2.07875
IL12RB1 interleukin 12 receptor, beta 1 2.059
S1PR4 sphingosine-1-phosphate receptor 4 2.0557
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.05535
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.0539
RAG2 recombination activating gene 2 2.0409
EIF3H eukaryotic translation initiation factor 3, subunit H 2.03535
EPN3 epsin 3 2.0345
GPR22 G protein-coupled receptor 22 2.01585
ZNF589 zinc finger protein 589 2.01295
GALE UDP-galactose-4-epimerase 2.0104
LOC122526780 uncharacterized LOC122526780 2.0048

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -10.0
FGFR4 fibroblast growth factor receptor 4 -6.97433
YME1L1 YME1-like 1 ATPase -6.8729
TLR4 toll-like receptor 4 -6.65985
MAPK13 mitogen-activated protein kinase 13 -6.3382
ERBB2 erb-b2 receptor tyrosine kinase 2 -5.24005
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.2232
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.19685
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.0292
LDHD lactate dehydrogenase D -5.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.90495
NUP93 nucleoporin 93kDa -4.64675
CHMP4B charged multivesicular body protein 4B -4.59438
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.5509
HAT1 histone acetyltransferase 1 -4.5391
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.5177
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.50515
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.2881
ZNF586 zinc finger protein 586 -3.90265
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.78055
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.7017
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.58105
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.51995
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.5195
NEO1 neogenin 1 -2.4725
ABI1 abl-interactor 1 -2.44858
OXA1L oxidase (cytochrome c) assembly 1-like -2.44455
TLCD3A TLC domain containing 3A -2.3656
GPR65 G protein-coupled receptor 65 -2.322
NID1 nidogen 1 -2.28333
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.27818
ZNF106 zinc finger protein 106 -2.253
HMG20B high mobility group 20B -2.2391
HLX H2.0-like homeobox -2.22285
PMVK phosphomevalonate kinase -2.2071
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.1647
TOR4A torsin family 4, member A -2.13815
HCAR3 hydroxycarboxylic acid receptor 3 -2.11475
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -2.1058
CIB1 calcium and integrin binding 1 (calmyrin) -2.04685
IPO4 importin 4 -2.0322
RASAL2 RAS protein activator like 2 -2.00415