CRCGN010_HEPG2_24H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methenamine 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN010_HEPG2_24H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PMM2 phosphomannomutase 2 6.01988
CIAO3 cytosolic iron-sulfur assembly component 3 5.47329
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 5.07437
MAMLD1 mastermind-like domain containing 1 4.94852
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.60581
RPP38 ribonuclease P/MRP 38kDa subunit 4.38284
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.05524
MEF2C myocyte enhancer factor 2C 4.04642
STIMATE STIM activating enhancer 4.02974
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.71489
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.49148
VGLL4 vestigial-like family member 4 3.28331
HEBP1 heme binding protein 1 2.95954
LOC122526780 uncharacterized LOC122526780 2.9354
GRWD1 glutamate-rich WD repeat containing 1 2.82037
DIPK1A divergent protein kinase domain 1A 2.75736
NMU neuromedin U 2.69159
HLA-DMA major histocompatibility complex, class II, DM alpha 2.53028
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.51574
EPHA3 EPH receptor A3 2.47114
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.46533
SLC75A1 solute carrier family 75 member 1 2.4372
TNIP1 TNFAIP3 interacting protein 1 2.41022
KAT6A K(lysine) acetyltransferase 6A 2.35704
CHN1 chimerin 1 2.32202
TENT4A terminal nucleotidyltransferase 4A 2.28244
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.26032
ZHX2 zinc fingers and homeoboxes 2 2.25113
ECI1 enoyl-CoA delta isomerase 1 2.22327
NCKIPSD NCK interacting protein with SH3 domain 2.20451
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.1834
PTH2R parathyroid hormone 2 receptor 2.17486
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.16131
GPATCH8 G patch domain containing 8 2.14888
ZNF589 zinc finger protein 589 2.1241
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.10558
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.08336
NT5DC2 5'-nucleotidase domain containing 2 2.08045
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.0785
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.07573
MYBPH myosin binding protein H 2.04814
LUC7L LUC7-like (S. cerevisiae) 2.02727

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -8.05852
TM9SF3 transmembrane 9 superfamily member 3 -5.94569
CDC20 cell division cycle 20 -5.06282
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.03849
CCNB2 cyclin B2 -4.88819
ADI1 acireductone dioxygenase 1 -4.87219
LDHD lactate dehydrogenase D -4.70802
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.68362
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.45636
PCNA proliferating cell nuclear antigen -4.09895
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.06984
ITGB1BP1 integrin beta 1 binding protein 1 -3.91634
WASHC4 WASH complex subunit 4 -3.85323
SCCPDH saccharopine dehydrogenase (putative) -3.81024
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.8049
SNX11 sorting nexin 11 -3.45781
PROS1 protein S (alpha) -3.243
TCTN1 tectonic family member 1 -3.1635
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.13668
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.1271
GNAS GNAS complex locus -3.05144
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.81401
NRIP1 nuclear receptor interacting protein 1 -2.72232
DCK deoxycytidine kinase -2.67499
TLR4 toll-like receptor 4 -2.61057
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.49709
CD58 CD58 molecule -2.49417
CRYZ crystallin, zeta (quinone reductase) -2.47572
LGMN legumain -2.47262
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.43592
PRPF4 pre-mRNA processing factor 4 -2.20772
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.14069
C5 complement component 5 -2.07589
OXA1L oxidase (cytochrome c) assembly 1-like -2.04422
IFT46 intraflagellar transport 46 -2.03596
GPN1 GPN-loop GTPase 1 -2.01368