CRCGN010_HEPG2_24H:H09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triclosan 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:H09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.94336
MAP7 microtubule-associated protein 7 5.79782
CNPY3 canopy FGF signaling regulator 3 4.97096
PNKP polynucleotide kinase 3'-phosphatase 4.77142
CBR3 carbonyl reductase 3 4.09257
NOSIP nitric oxide synthase interacting protein 4.07892
HMOX1 heme oxygenase 1 4.02222
NOTCH1 notch 1 3.8629
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.73979
STIMATE STIM activating enhancer 3.72883
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.52767
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.49448
GSTZ1 glutathione S-transferase zeta 1 3.10842
RXYLT1 ribitol xylosyltransferase 1 2.68386
RRAGA Ras-related GTP binding A 2.50516
MYLK myosin light chain kinase 2.50113
PLSCR1 phospholipid scramblase 1 2.41795
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.11974
MCM3 minichromosome maintenance complex component 3 2.11227
AVEN apoptosis, caspase activation inhibitor 2.10884
CCNF cyclin F 2.08391
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.07244
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.05623
HSPA8 heat shock 70kDa protein 8 2.01338
UGDH UDP-glucose 6-dehydrogenase 2.0071

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.69444
LDHD lactate dehydrogenase D -6.44322
CCDC86 coiled-coil domain containing 86 -6.01835
OXA1L oxidase (cytochrome c) assembly 1-like -5.65583
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.6438
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.38623
CCNB2 cyclin B2 -4.22811
RNF167 ring finger protein 167 -3.87375
CDC25B cell division cycle 25B -3.81915
PCNA proliferating cell nuclear antigen -3.5094
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.23659
NUP85 nucleoporin 85kDa -3.23221
FAIM Fas apoptotic inhibitory molecule -3.16918
RFC2 replication factor C (activator 1) 2, 40kDa -3.14234
ALAS1 5'-aminolevulinate synthase 1 -3.10127
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.09936
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.00184
FBXL12 F-box and leucine-rich repeat protein 12 -2.90466
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.8966
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.86747
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.84697
PEG10 paternally expressed 10 -2.74742
FASTKD5 FAST kinase domains 5 -2.71233
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.5863
DSG2 desmoglein 2 -2.48957
SPAG4 sperm associated antigen 4 -2.48044
PECR peroxisomal trans-2-enoyl-CoA reductase -2.45341
TCTN1 tectonic family member 1 -2.40952
KCTD2 potassium channel tetramerization domain containing 2 -2.26798
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.26049
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.23958
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.10318
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.09982
SLC22A14 solute carrier family 22, member 14 -2.09007
SMG8 SMG8 nonsense mediated mRNA decay factor -2.07653
TCERG1 transcription elongation regulator 1 -2.04989
SEPHS2 selenophosphate synthetase 2 -2.01618
SCARA3 scavenger receptor class A, member 3 -2.00305