CRCGN010_HEPG2_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triclosan 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN010_HEPG2_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 10.0
RPP38 ribonuclease P/MRP 38kDa subunit 5.34997
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.32978
CIAO3 cytosolic iron-sulfur assembly component 3 5.28629
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.26927
SYNE2 spectrin repeat containing, nuclear envelope 2 4.52484
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.31726
MAP7 microtubule-associated protein 7 4.00826
RAB21 RAB21, member RAS oncogene family 3.92173
SFTPB surfactant protein B 3.87854
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.74811
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.61227
EVL Enah/Vasp-like 3.59855
NOSIP nitric oxide synthase interacting protein 3.25342
C2CD2 C2 calcium-dependent domain containing 2 3.25044
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.24643
NMU neuromedin U 3.11094
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.08198
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.07615
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.93413
CHN1 chimerin 1 2.89991
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.88972
ABHD4 abhydrolase domain containing 4 2.81566
HLA-DRA major histocompatibility complex, class II, DR alpha 2.73977
CYCS cytochrome c, somatic 2.67432
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.62992
SSBP2 single-stranded DNA binding protein 2 2.51631
RPA3 replication protein A3, 14kDa 2.45253
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.39551
HDAC2 histone deacetylase 2 2.38396
TMSB10 thymosin beta 10 2.30799
MYOD1 myogenic differentiation 1 2.19301
GPATCH8 G patch domain containing 8 2.18345
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.16928
DHDDS dehydrodolichyl diphosphate synthase 2.14734
CD34 CD34 molecule 2.13735
TRDMT1 tRNA aspartic acid methyltransferase 1 2.13704
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.12147
FPGS folylpolyglutamate synthase 2.09571
MTUS2 microtubule associated tumor suppressor candidate 2 2.07244
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.05836
CHEK2 checkpoint kinase 2 2.0566
POLR1G RNA polymerase I subunit G 2.03017
EPHA3 EPH receptor A3 2.02728
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.0088
S100PBP S100P binding protein 2.00859

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.87206
VAT1 vesicle amine transport 1 -5.81958
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.29121
CCNB2 cyclin B2 -4.93689
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.61899
PCNA proliferating cell nuclear antigen -4.37988
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.3557
NRIP1 nuclear receptor interacting protein 1 -3.97951
WDR7 WD repeat domain 7 -3.67253
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.60007
SNX11 sorting nexin 11 -3.20362
SLC35F2 solute carrier family 35, member F2 -3.0775
MAPK13 mitogen-activated protein kinase 13 -2.98363
CAB39 calcium binding protein 39 -2.85236
TWF2 twinfilin actin binding protein 2 -2.76197
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.68538
ITGB1BP1 integrin beta 1 binding protein 1 -2.50548
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.48739
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.43329
LOC124907782 dual specificity protein phosphatase 22 -2.43073
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.19311
CILK1 ciliogenesis associated kinase 1 -2.06681
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0273