CRCGN010_HEPG2_24H:H15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorendic acid 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

201 genes differentially expressed following the CRCGN010_HEPG2_24H:H15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 8.39505
LCN2 lipocalin 2 6.87475
C2CD2 C2 calcium-dependent domain containing 2 6.1447
CXCL2 chemokine (C-X-C motif) ligand 2 6.05695
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.5431
ANO10 anoctamin 10 5.36875
NMU neuromedin U 5.3092
GFOD1 glucose-fructose oxidoreductase domain containing 1 5.2784
EDN1 endothelin 1 5.22025
CBR1 carbonyl reductase 1 5.12725
ABHD4 abhydrolase domain containing 4 4.961
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.91395
BZW2 basic leucine zipper and W2 domains 2 4.82895
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.81885
EPHB2 EPH receptor B2 4.80989
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.8054
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.66275
ZBTB35 zinc finger and BTB domain containing 35 4.4735
TIAM1 T-cell lymphoma invasion and metastasis 1 4.25445
AXIN1 axin 1 4.17635
ZNF589 zinc finger protein 589 4.05115
H2BC12 H2B clustered histone 12 3.9938
RXYLT1 ribitol xylosyltransferase 1 3.79905
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.77475
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.70448
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.62149
MCM3 minichromosome maintenance complex component 3 3.5901
SCYL3 SCY1-like 3 (S. cerevisiae) 3.51008
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.4912
AMDHD2 amidohydrolase domain containing 2 3.4317
MCUR1 mitochondrial calcium uniporter regulator 1 3.35055
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.25695
MAP7 microtubule-associated protein 7 3.01332
UBE2A ubiquitin-conjugating enzyme E2A 2.87772
SKIC2 SKI2 subunit of superkiller complex 2.86265
TSPAN6 tetraspanin 6 2.82422
CBR3 carbonyl reductase 3 2.8093
FZD7 frizzled class receptor 7 2.80383
NUCB2 nucleobindin 2 2.80015
INSIG1 insulin induced gene 1 2.80015
GATA3 GATA binding protein 3 2.789
RRAGA Ras-related GTP binding A 2.75295
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.73277
PCDH8 protocadherin 8 2.7165
ICAM1 intercellular adhesion molecule 1 2.68728
SSBP2 single-stranded DNA binding protein 2 2.65107
ADAM10 ADAM metallopeptidase domain 10 2.61538
NYNRIN NYN domain and retroviral integrase containing 2.60195
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.59127
EFS embryonal Fyn-associated substrate 2.58672
GDF10 growth differentiation factor 10 2.5206
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.5079
BBLN bublin coiled coil protein 2.44722
GARRE1 granule associated Rac and RHOG effector 1 2.4405
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.43015
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.4285
TCHH trichohyalin 2.42185
UNC13D unc-13 homolog D (C. elegans) 2.4103
CTTN cortactin 2.4014
TBCC tubulin folding cofactor C 2.39205
VWF von Willebrand factor 2.38925
EPHA3 EPH receptor A3 2.3718
CAPNS1 calpain, small subunit 1 2.35485
RAB4A RAB4A, member RAS oncogene family 2.31945
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.31105
ANKRD10 ankyrin repeat domain 10 2.3088
CCS copper chaperone for superoxide dismutase 2.29255
PTK2 protein tyrosine kinase 2 2.29148
TREM1 triggering receptor expressed on myeloid cells 1 2.28825
E2F2 E2F transcription factor 2 2.2878
SH3D19 SH3 domain containing 19 2.28067
RPP40 ribonuclease P/MRP 40kDa subunit 2.2587
E2F8 E2F transcription factor 8 2.2586
NCOA3 nuclear receptor coactivator 3 2.24832
SOX18 SRY (sex determining region Y)-box 18 2.24005
ITGB6 integrin, beta 6 2.23513
STK17B serine/threonine kinase 17b 2.23287
CDPF1 cysteine-rich, DPF motif domain containing 1 2.216
LPAR2 lysophosphatidic acid receptor 2 2.2117
FZD4 frizzled class receptor 4 2.21005
ITM2A integral membrane protein 2A 2.20795
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.2068
LHX2 LIM homeobox 2 2.2052
NUP133 nucleoporin 133kDa 2.19905
MOK MOK protein kinase 2.1966
ADRB2 adrenoceptor beta 2, surface 2.19605
ADRA1D adrenoceptor alpha 1D 2.19405
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.1814
TRIM36 tripartite motif containing 36 2.1757
CPA1 carboxypeptidase A1 (pancreatic) 2.1718
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.15715
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.12565
VTCN1 V-set domain containing T cell activation inhibitor 1 2.1187
ABLIM1 actin binding LIM protein 1 2.11508
GRHL2 grainyhead-like 2 (Drosophila) 2.11365
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.1119
H2AC4 H2A clustered histone 4 2.09805
CDK9 cyclin-dependent kinase 9 2.0907
NPTXR neuronal pentraxin receptor 2.08815
JAK1 Janus kinase 1 2.0881
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.086
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.0798
ZNF460 zinc finger protein 460 2.07285
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.07142
PREB prolactin regulatory element binding 2.07005
DHDDS dehydrodolichyl diphosphate synthase 2.06328
MEF2B myocyte enhancer factor 2B 2.06145
MELK maternal embryonic leucine zipper kinase 2.05905
SH3GL3 SH3-domain GRB2-like 3 2.0558
PYCR3 pyrroline-5-carboxylate reductase 3 2.05405
KIAA0319 KIAA0319 2.0509
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.04155
PRKCB protein kinase C, beta 2.018
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.0151
TDRKH tudor and KH domain containing 2.01328

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -9.8211
CDC25B cell division cycle 25B -7.37565
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -6.71595
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -6.59175
C2CD5 C2 calcium-dependent domain containing 5 -5.21905
PCNA proliferating cell nuclear antigen -5.21485
ZW10 zw10 kinetochore protein -5.16025
DERA deoxyribose-phosphate aldolase (putative) -5.0756
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.0215
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.9939
NRIP1 nuclear receptor interacting protein 1 -4.87208
CCNB2 cyclin B2 -4.80115
TLR4 toll-like receptor 4 -4.5865
TMEM109 transmembrane protein 109 -4.57605
XPO7 exportin 7 -4.1906
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.1404
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.1086
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.01115
CAB39 calcium binding protein 39 -3.9908
HMG20B high mobility group 20B -3.87038
NGRN neugrin, neurite outgrowth associated -3.86
GSTM2 glutathione S-transferase mu 2 (muscle) -3.8385
PECR peroxisomal trans-2-enoyl-CoA reductase -3.77875
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.41345
RPS5 ribosomal protein S5 -3.1828
LHB luteinizing hormone beta polypeptide -3.16665
NT5DC2 5'-nucleotidase domain containing 2 -3.1614
MTFR1 mitochondrial fission regulator 1 -3.13297
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -3.07695
MVP major vault protein -3.04525
BLMH bleomycin hydrolase -3.0335
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -3.00207
MTA1 metastasis associated 1 -2.99382
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.9557
RBM15B RNA binding motif protein 15B -2.846
SPDEF SAM pointed domain containing ETS transcription factor -2.78448
PLA2G15 phospholipase A2, group XV -2.7714
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.73673
CPNE3 copine III -2.71655
RPIA ribose 5-phosphate isomerase A -2.6579
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.6165
TCTN1 tectonic family member 1 -2.52715
DUSP14 dual specificity phosphatase 14 -2.52495
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.5101
VDAC1 voltage-dependent anion channel 1 -2.50207
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.4809
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.4401
NOL11 nucleolar protein 11 -2.4358
RNF167 ring finger protein 167 -2.43455
MUC6 mucin 6, oligomeric mucus/gel-forming -2.4281
CERK ceramide kinase -2.3987
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.39595
WASHC4 WASH complex subunit 4 -2.39582
ALDOC aldolase C, fructose-bisphosphate -2.38455
NLRP4 NLR family, pyrin domain containing 4 -2.36605
DCK deoxycytidine kinase -2.34605
HOXA5 homeobox A5 -2.3211
POMT2 protein-O-mannosyltransferase 2 -2.3005
CXXC4 CXXC finger protein 4 -2.29775
AEN apoptosis enhancing nuclease -2.26795
PDCD5 programmed cell death 5 -2.2557
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.2515
IL4R interleukin 4 receptor -2.24905
KCTD2 potassium channel tetramerization domain containing 2 -2.24635
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -2.22325
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -2.19565
ZDHHC6 zinc finger, DHHC-type containing 6 -2.16705
ANKLE2 ankyrin repeat and LEM domain containing 2 -2.14687
SMC3 structural maintenance of chromosomes 3 -2.1417
COBL cordon-bleu WH2 repeat protein -2.13835
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.13215
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.11865
ZNF668 zinc finger protein 668 -2.1074
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.105
NCK2 NCK adaptor protein 2 -2.0893
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.07115
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.0706
CHIC2 cysteine-rich hydrophobic domain 2 -2.06765
STK25 serine/threonine kinase 25 -2.0665
PRDM4 PR domain containing 4 -2.05695
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -2.05595
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.0412
DDIT4 DNA-damage-inducible transcript 4 -2.0237
PCBP4 poly(rC) binding protein 4 -2.009
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.00845
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.00065